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  • C4607 - Anti-Cdk1 (p34cdc2) antibody produced in rabbit

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C4607 Sigma

Anti-Cdk1 (p34cdc2) antibody produced in rabbit

whole antiserum

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle, Antibodies for Kinase/Phosphatase Biology,
species reactivity   rat (predicted), mouse, human (predicted)
application(s)   immunoprecipitation: suitable
  western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates
clone   polyclonal
antibody form   whole antiserum
mol wt   antigen mol wt 34 kDa
contains   0.05% sodium azide as preservative
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.

General description

The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.

Application

Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.

Biochem/physiol Actions

Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.

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