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C4642 Sigma

α-Cyclodextrin

≥98%

Synonym: α-Schardinger dextrin, Cyclohexaamylose, Cyclomaltohexaose, alpha-Cyclodextrin

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Synthetic Reagents
Quality Level   PREMIUM
assay   ≥98%
mp   >278 °C (dec.)(lit.)
solubility   H2O: soluble50 mg/mL

Description

Packaging

1, 5, 25 g in poly bottle

Price and Availability

Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds i...
Vicki Caligur
BioFiles 2008, 3.3, 32.
Keywords: Applications, Cell culture, Hormones, Nuclear magnetic resonance spectroscopy, Substitutions, Vitamins

Peer-Reviewed Papers

References

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Photoswitchable gel assembly based on molecular recognition. Yamaguchi H, Kobayashi Y, Kobayashi R, et al. Nat. Commun. 3, 603, (2012)

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Expansion-contraction of photoresponsive artificial muscle regulated by host-guest interactions. Takashima Y, Hatanaka S, Otsubo M, et al. Nat. Commun. 3, 1270, (2012)

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Formulations based on alpha cyclodextrin and soybean oil: an approach to modulate the oral release of lipophilic drugs. Hamoudi MC, Bourasset F, Domergue-Dupont V, et al. J. Control. Release 161(3), 861-7, (2012)

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Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier. Arima H, Yoshimatsu A, Ikeda H, et al. Mol. Pharm. 9(9), 2591-604, (2012)

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An initial investigation into the anti-inflammatory activity and antioxidant capacity of alpha-cyclodextrin-complexed Manuka honey. Chepulis LM and Francis E J. Complement. Integr. Med. 9, Article 25, (2012)

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A quantitative study of intrinsic non-covalent interactions within complexes of α-cyclodextrin and benzoate derivatives. Li Z, Couzijn EP, and Zhang X Chem. Commun. (Camb.) 48(79), 9864-6, (2012)

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Receptor-mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes. Zhou Y, Wang H, Wang C, et al. Mol. Pharm. 9(5), 1067-76, (2012)

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Potential use of lactosylated dendrimer (G3)/α-cyclodextrin conjugates as hepatocyte-specific siRNA carriers for the treatment of familial amyloidotic polyneuropathy. Hayashi Y, Mori Y, Yamashita S, et al. Mol. Pharm. 9(6), 1645-53, (2012)

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Carbohydrates as additives for the formation of isoporous PS-b-P4VP diblock copolymer membranes. Clodt JI, Rangou S, Schröder A, et al. Macromol. Rapid Commun. 34(2), 190-4, (2013)

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Fabrication of novel coumarin derivative functionalized polypseudorotaxane micelles for drug delivery. Chang J, Li Y, Wang G, et al. Nanoscale 5(2), 813-20, (2013)

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Cations in a molecular funnel: vibrational spectroscopy of isolated cyclodextrin complexes with alkali metals. Gámez F, Hurtado P, Hortal AR, et al. ChemPhysChem 14(2), 400-7, (2013)

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Application of time-of-flight aerosol mass spectrometry for the online measurement of gaseous molecular iodine. Kundel M, Huang RJ, Thorenz UR, et al. Anal. Chem. 84(3), 1439-45, (2012)

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Unraveling unidirectional threading of α-cyclodextrin in a [2]rotaxane through spin labeling approach. Casati C, Franchi P, Pievo R, et al. J. Am. Chem. Soc. 134(46), 19108-17, (2012)

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Beads made of α-cyclodextrin and soybean oil: the drying method influences bead properties and drug release. Hamoudi MC, Saunier J, Gueutin C, et al. Drug Dev. Ind. Pharm. 39(9), 1306-14, (2013)

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Possible enhancing mechanisms for gene transfer activity of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate. Anno T, Higashi T, Motoyama K, et al. Int. J. Pharm. 426(1-2), 239-47, (2012)

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An intelligent anticorrosion coating based on pH-responsive supramolecular nanocontainers. Chen T and Fu J Nanotechnology 23(50), 505705, (2012)

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Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/α-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy. Hayashi Y, Mori Y, Higashi T, et al. Amyloid 19 Suppl 1, 47-9, (2012)

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Photoreversible polymer-surfactant micelles using the molecular recognition of α-cyclodextrin. Dong ZQ, Cao Y, Han XJ, et al. Langmuir 29(10), 3188-94, (2013)

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Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells. Arima H, Arizono M, Higashi T, et al. Cancer Gene Ther. 19(5), 358-66, (2012)

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α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies. Shityakov S, Broscheit J, and Förster C Int. J. Nanomedicine 7, 3211-9, (2012)

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Cyclodextrin modified quantum dots with tunable liquid-like behaviour. Zhou J, Huang J, Tian D, et al. Chem. Commun. (Camb.) 48(30), 3596-8, (2012)

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Photoconductive properties of a π-conjugated α-cyclodextrin containing [2]rotaxane and its corresponding molecular dumbbell. Deligkiozi I, Papadakis R, and Tsolomitis A Phys. Chem. Chem. Phys. 15(10), 3497-503, (2013)

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Structure determination of fexofenadine-α-cyclodextrin complex by quantitative 2D ROESY analysis and molecular mechanics studies. Ali SM, Khan S, and Crowyn G Magn. Reson. Chem. 50(4), 299-304, (2012)

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Selective nanodecoration of modified cyclodextrin crystals with gold nanorods. Herrera B, Adura C, Yutronic N, et al. J. Colloid. Interface Sci. 389(1), 42-5, (2013)

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α-Cyclodextrin decreases cholera toxin binding to GM1-gangliosides. Ermolinsky B, Peredelchuk M, and Provenzano D J. Med. Microbiol. 62(Pt 7), 1011-4, (2013)

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[Polyfection as nonviral gene transfer method -design of novel nonviral vector using alpha-cyclodextrin]. Arima H Yakugaku Zasshi 124(7), 451-64, (2004)

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Self-assembly of chitosan-g-PEG and α-cyclodextrin into hollow spheres in aqueous solution. Ha W, Fan MM, Zhang S, et al. J. Control. Release 152 Suppl 1, e204-5, (2011)

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Merck 14,2718

Beil. 19,V,12,789

Aldrich MSDS 1, 507:C / Corp MSDS 1 (1), 952:A / FT-IR 2 (1), 288:A / FT-IR 1 (1), 197:D / IR-Spectra (3), 119:H / IR-Spectra (2), 110:G / RegBook 1 (1), 199:B / Sigma FT-IR 1 (1), 1159:D / Structure Index 1, 27:C:7

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