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C4733 Sigma

BID, Caspase-8-cleaved from mouse

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution

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Properties

Related Categories Apoptosis and Cell Cycle, Bcl-2 Family Proteins, Bcl-2 Family Proteins and Antibodies, Cell Biology, Cell Signaling and Neuroscience More...
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Bid(12122)

Description

Analysis Note

Measured by its ability to induce cytochrome c release from isolated mouse liver mitochondria.

Biochem/physiol Actions

Caspase-8-cleaved BID relocates from the cytosol to the outer mitochondrial membrane where its interaction with Bak alters mitochondrial membrane permeability.

Physical form

0.2 μm filtered solution in 25 mM HEPES, pH 7.5, and 0.1 M KCl.

General description

Mouse BID cleaved with caspase-8 generates the amino-terminal fragment (amino acids 1-59, 7 kDa) and the carboxy-terminal fragment (amino acids 60-195, 15 kDa). On size exclusion chromatography cleaved BID elutes at 27 kDa indicating that the fragments remain associated.

Price and Availability


Flow Cytometry Instruments
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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