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C4748 Sigma

Anti-COX6A2 (51-65) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-COX6AH, Anti-COXVIAH, Anti-Cytochrome c oxidase polypeptide VIa-heart, mitochondrial precursor

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Related Categories Alphabetical Index, Antibodies, CO-CP, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~11 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... COX6A2(1339)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 51-65 of human COX6A2

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Cytochrome c oxidase (COX) is a terminal enzyme of the mitochondrial respiratory chain. One of the 13 subunits of the respiratory chain complex IV (cytochrome c oxidase) is the COX6A protein. Two different mammalian COX6A isoforms, COX6A1 (liver-type) and COX6A2 (heart-type), vary in their expression and regulation. The expression of COX6A2 is restricted to striated muscles. It binds to ADP and ATP. COX6A2 is also expressed in skeletal muscle and regulates oxidative phosphorylation. COX6A2 deficiency results in a moderate decrease in complex IV enzymatic activity and increased production of reactive oxygen species production (ROS) in contracting skeletal muscle.

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Safety Information

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Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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