Synonym: (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt
|Related Categories||Antagonists, Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecules, Biochemicals and Reagents,|
|Gene Information||human ... HRH1(3269)|
H1 histamine receptor antagonist; active isomer.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25|
|Safety Statements (Europe)||36/37/39-45|
|RIDADR||UN 2811 6.1 / PGIII|
The biogenic amine histamine plays an important role in a variety of pathophysiological conditions. In peripheral tissues, histamine is mainly stored in mast cells and basophils. In allergic conditio...
Keywords: Alzheimer Disease, Atomic absorption spectroscopy, Cardiovascular, Clinical, Diseases, Gene expression, Inflammation, Ligands, Neurotransmitters, Obesity, Transduction
Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. Akaishi, Y., et al. Br. J. Pharmacol. 130, 907-915, (2000)
The Effect Of Thymoquinone, The Main Constituent Of Nigella Sativa On Tracheal Responsiveness And White Blood Cell Count In Lung Lavage Of Sensitized Guinea Pigs. Keyhanmanesh, R., et al. Planta Med. 76, 218-22, (2010)
Focal rituximab-induced edematous reaction at primary cutaneous follicle center lymphoma lesions: case report and literature review. Brunet-Possenti F, Franck N, Tamburini J, et al. Dermatology 223(3), 200-2, (2011)
Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased. Van Ruitenbeek P, Vermeeren A, and Riedel WJ Eur. Neuropsychopharmacol. 20(4), 226-35, (2010)
Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study. Moreno RA, Oliveira-Silva D, Sverdloff CE, et al. Biomed. Chromatogr. 24(7), 774-81, (2010)
[Efficacy of premedication with intravenous corticosteroids and antihistaminics in preventing infusion reactions to infliximab]. Bermejo F, López San Román A, Algaba A, et al. Gastroenterol. Hepatol. 31(10), 629-32, (2008)
[Description of an outbreak of lepidopterism (dermatitis associated with contact with moths) among sailors in Salvador, State of Bahia]. Moreira SC, de Lima JC, Silva L, et al. Rev. Soc. Bras. Med. Trop. 40(5), 591-3, (2007)
Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance. Theunissen EL, Vermeeren A, and Ramaekers JG Br. J. Clin. Pharmacol. 61(1), 79-86, (2006)
Derivative ultraviolet spectrophotometric determination of dexchlorpheniramine maleate in tablets in presence of coloring agents. Viana NS, Moreira-Campos LM, and Vianna-Soares CD Farmaco 60(11-12), 900-5, (2005)
A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo. Theunissen EL, Vermeeren A, van Oers AC, et al. Clin. Exp. Allergy 34(2), 250-8, (2004)
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