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C5051 Sigma

C-Peptide human

≥95% (HPLC)

Synonym: Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg, Insulin C chain

  • CAS Number 11097-48-6

  • Empirical Formula (Hill Notation) C153H259N49O52

  • Molecular Weight 3616.99

  •  MDL number MFCD00076294

  •  PubChem Substance ID 329775074

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Insulin Peptides, Peptides and Proteins,
InChI Key   JEPNOJXFZHBCTB-ZCUALFGZSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C
Gene Information   human ... INS(3630)

Description

Biochem/physiol Actions

In proinsulin the insulin A and B chains are linked by C peptide. During the biosynthesis of insulin, the C peptide promotes proper protein folding and disulfide bond placement after which it is cleaved. The cleaved peptide may inhibit insulin aggregation and is stored and released from the β cells with insulin in a one-to-one molar ratio. C peptide is a marker for β cell function in vivo; levels are enhanced in insulin resistance or insuloma and reduced in insulin insufficiency (type I diabetes). C peptide may alleviate the vascular damage and neuropathy associated with insulin depletion.

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Amplified Detection

Amicon Ultra Centrifugal Filters
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Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
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