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C5135 Sigma

Kolliphor® EL

pH-range 6.0 - 8.0

Synonym: Cremophor® EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl 35 hydrogenated castor oil, Polyoxyl-35 castor oil

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Properties

Related Categories Biochemicals and Reagents, Detergents, Detergents A to M, Excipients for R&D Use Only, Non-Ionic Detergents,
description   non-ionic
pH-range   6.0 - 8.0

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Used to emulsify and solubilize oils and other water-insoluble substances. Cremophor is the brand name for a range of non-ionic polyethoxylated detergents. It was originally developed for use as solubilizers and emulsifiers.
This research grade product is intended for use in R&D and development only.

Kolliphor® EL has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells.

Other Notes

A derivative of castor oil and ethylene oxide.

General description

Kolliphor® EL is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odor. Kolliphor EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.

Legal Information

Cremophor is a registered trademark of BASF SE

Kolliphor is a registered trademark of BASF

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What solvents can I use to prepare a solution of Cremophor EL (Product No. C5135)? Or is it already in solution?
Cremophor EL is a neat liquid, sold by weight. It is not already in solution. It is soluble in water; note that the solubility in water actually decreases with an increase in temperature. It is also soluble in many organic solvents, such as ethanol, isopropyl alcohol, chloroform and others.
What is the hydrophile-lipophile balance (HLB) for Cremophor EL (Product No. C5135)?
The manufacturer (BASF) reports an HLB value of between 12 and 14 for Cremophor EL (Product No. C5135).
What is the molecular weight of Cremophor EL (Product No. C5135)?
The manufacturer (BASF) reports a molecular weight of approximately 2500 for Cremophor EL (Product No. C5135).
How can Cremophor EL (Product No. C5135) be sterilized?
The manufacturer (BASF) recommends that it be sterilized by heating in an autoclave for 30 minutes at 120°C. It may acquire a somewhat deeper color. Either the neat material or neutral aqueous solutions may be autoclaved.
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Protocols & Articles
Peer-Reviewed Papers
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References

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