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C5145 Sigma

Chlormadinone acetate

≥98%

Synonym: 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione, 6-Chloro-6-dehydro-17α-acetoxyprogesterone, 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate, Gestafortin, Matrol, Menstridyl

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Properties

assay   ≥98%

Description

Biochem/physiol Actions

Review of progestogenic and related pharmacological effects of chlormadinone acetate.1

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
3
RTECS 
TU3750000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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1. Profile of the progesterone derivative chlormadinone acetate - pharmocodynamic properties and therapeutic applications Druckmann, R. Contraception 79, 272-281, (2009)

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Pregnane progestin contraception in systemic lupus erythematosus: a longitudinal study of 187 patients. Chabbert-Buffet N, Amoura Z, Scarabin PY, et al. Contraception 83(3), 229-37, (2011)

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[Changes in serum prostate specific antigen and testosterone levels after chlormadinone acetate treatment in patients with benign prostatic hyperplasia : a prospective multicenter clinical study]. Fujimoto K, Hirao Y, Ohashi Y, et al. Hinyokika Kiyo. 57(4), 177-83, (2011)

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[Transurethral resection for prostatic adenoma larger than 100 ml--preoperative treatment with interstitial laser coagulation of the prostate plus chlormadinone acetate as a treatment maneuver for safer operations]. Furuya S, Furuya R, Ogura H, et al. Hinyokika Kiyo. 51(3), 159-64, (2005)

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Ethinylestradiol/Chlormadinone acetate for use in dermatological disorders. Gómez Vázquez M, Navarra Amayuelas R, Lamarca M, et al. Am. J. Clin. Dermatol. 12 Suppl 1, 13-9, (2011)

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The effects of 2 mg chlormadinone acetate/30 mcg ethinylestradiol, alone or combined with spironolactone, on cardiovascular risk markers in women with polycystic ovary syndrome. Vieira CS, Martins WP, Fernandes JB, et al. Contraception 86(3), 268-75, (2012)

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Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome. De Leo V, Di Sabatino A, Musacchio MC, et al. Contraception 82(3), 276-80, (2010)

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An open trial of long-term testosterone suppression in spinal and bulbar muscular atrophy. Yamamoto T, Yokota K, Amao R, et al. Muscle Nerve 47(6), 816-22, (2013)

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Endocrinological, metabolic and clinical features of treatment with oral contraceptive formulation containing ethinylestradiol plus chlormadinone acetate in nonobese women with polycystic ovary syndrome. Uras R, Orrù M, Pani F, et al. Contraception 82(2), 131-8, (2010)

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Ethinylestradiol/Chlormadinone acetate: dermatological benefits. Guerra-Tapia A and Sancho Pérez B Am. J. Clin. Dermatol. 12 Suppl 1, 3-11, (2011)

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Inhibitory potential of chlormadinone acetate (CMA) on five important UDP-glucuronosyltransferases in human liver. Huang T, Fang ZZ, Zhang YY, et al. Pharmazie 66(3), 212-5, (2011)

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The efficacy and safety of an oral contraceptive containing chlormadinone acetate: results of a pooled analysis of noninterventional trials in adult and adolescent women. Schramm GA and Schrah G Contraception 84(4), 390-401, (2011)

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Estrus induction in white rhinoceros (Ceratotherium simum). Hermes R, Hildebrandt TB, Walzer C, et al. Theriogenology 78(6), 1217-23, (2012)

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Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome. Gomes VA, Vieira CS, Jacob-Ferreira AL, et al. Basic Clin Pharmacol Toxicol. 111(3), 211-6, (2012)

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Chlormadinone acetate (CMA) in oral contraception--a new opportunity. Bouchard P Eur. J. Contracept. Reprod. Health Care 10 Suppl 1, 7-11, (2005)

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Endometrial safety of a novel monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen over six cycles. Rabe T, Hartschuh E, Wahlstrom T, et al. Contraception 82(4), 358-65, (2010)

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Chlormadinone acetate suppresses prostaglandin biosynthesis in human endometrial explants. Hanjalic-Beck A, Schäfer WR, Deppert WR, et al. Fertil. Steril. 98(4), 1017-22, (2012)

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Evaluation of efficacy, safety and effects on symptoms of androgenization of a generic oral contraceptive containing chlormadinone acetate 2 mg/ethinylestradiol 0.03 mg. Hadji P, Biskup J, Boekhoff J, et al. Contraception 86(4), 359-65, (2012)

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Effects of an oral contraceptive containing chlormadinone acetate and ethinylestradiol on hair and skin quality in women wishing to use hormonal contraception. Kerscher M, Reuther T, Krueger N, et al. J. Eur. Acad. Dermatol. Venereol. 27(5), 601-8, (2013)

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Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: a single-center experience. Okegawa T, Nutahara K, and Higashihara E Int. J. Urol. 17(11), 950-5, (2010)

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Ethinylestradiol-chlormadinone acetate combination for the treatment of hirsutism and hormonal alterations of normal-weight women with polycystic ovary syndrome: evaluation of the metabolic impact. Guido M, Romualdi D, Campagna G, et al. Reprod. Sci. 17(8), 767-75, (2010)

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Extended cycles with the combined oral contraceptive chlormadinone acetate 2 mg/ethinylestradiol 0.03 mg: pooled analysis of data from three large-scale, non-interventional, observational studies. Göretzlehner G, Waldmann-Rex S, and Schramm GA Clin. Drug Investig. 31(4), 269-77, (2011)

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Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid. Altun D, Uysal H, Ayar A, et al. Toxicol. Ind. Health 27(1), 29-33, (2011)

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Safety data and beneficial effects of the combined oral contraceptive ethinylestradiol 0.03 mg/chlormadinone acetate 2 mg (Belara®): a 13-cycle, observational study in routine clinical practice. Pushparajah DS, Röhm P, Höschen K, et al. Clin. Drug Investig. 31(2), 121-34, (2011)

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Clinical efficacy of primary combined androgen blockade for Japanese men with clinically localized prostate cancer unsuitable for local definitive treatment: a single institution experience. Kobayashi M, Nukui A, Suzuki K, et al. Int. J. Clin. Oncol. 16(6), 630-6, (2011)

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Suppressive effects of the antiandrogen agent, chlormadinone acetate and the 5alpha-reductase inhibitor, dutasteride on prostate weight and intraprostatic androgen levels in rats. Kobayashi H, Gotanda K, Shibata Y, et al. Arzneimittelforschung 61(9), 515-20, (2011)

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[Hemicentral retinal artery occlusion due to oral contraceptives]. Schmidt D and Kramer-Zucker A Klin. Monbl. Augenheilkd. 228(8), 729-33, (2011)

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These dermatological disorders share the features of being caused by hyperactivity of androgen within the pilosebaceous follicle, and although not life threatening are the source of a considerable psychological and emotional burden for patients. Foreword. Maloney JM Am. J. Clin. Dermatol. 12 Suppl 1, 1-2, (2011)

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Merck 14,2102

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