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C5174 Sigma

4′-Chlorodiazepam

≥98% (TLC)

Synonym: 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one, Ro 5-4864, Ro5-4864

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Properties

Related Categories Benzodiazepines and Anxiolytics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
InChI Key   PUMYFTJOWAJIKF-UHFFFAOYSA-N
assay   ≥98% (TLC)
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
solubility   2-hydroxypropyl-β-cyclodextrin: insoluble
  H2O: insoluble
Gene Information   rat ... Tspo(24230)

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DF0500000
Protocols & Articles
Peer-Reviewed Papers
15

References

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