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C5483 Sigma

Collagen human

Bornstein and Traub Type I, acid soluble, powder, ~95% (SDS-PAGE)

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Properties

Related Categories Biochemicals and Reagents, Collagen, Proteins and Derivatives, Structural Proteins
assay   ~95% (SDS-PAGE)
form   powder
solubility   aqueous acid: ≤5 mg/mL
storage temp.   2-8°C
Gene Information   human ... COL1A2(1278)

Description

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Packaging

1 mg in glass bottle

Preparation Note

Prepared from human skin by modification of Gallop, P.M.

Application

Collagen type I may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type I is one distinctive feature of IPF. Additionally, collagen-type I has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collagen-type I soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.

Collagen Type I has been used as a scaffold for the growth in vitro of stem cells in a wide variety of biomaterial engineering studies.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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