Collagen from human placenta
Bornstein and Traub Type IV, powder, BioReagent, suitable for cell culture
DOWNLOAD MSDS (PDF)Synonym: Collagen Type 4
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CAS Number 9007-34-5
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EC Number 232-697-4
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MDL number MFCD00130825
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | 2D Cell Culture, Adhesion, Attachment, and Matrix Factors, Adhesion, Attachment, and Matrix Factors for Stem Cell Expansion, Attachment Factors, Attachments Factors, |
| product line | BioReagent |
| form | powder |
| impurities | HIV and hepatitis B, none detected (PCR) |
| HIV and hepatitis B, none detected | |
| solubility | acetic acid: soluble0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.) |
| suitability | suitable for cell culture |
| storage temp. | −20°C |
Description
Application
Epithelial cells, endothelial cells, muscle cells, nerve cells
General description
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Type IV collagen is highly expressed in chorionic villi cytotrophoblast cells. The same cells are also capable of expressing the cleaving enzyme, 70S type IV collagenase.1
Preparation Note
Prepared by a modification of the pepsin extraction method of Niyibizi, C. et. al
Biochem/physiol Actions
Type IV collagen is a sheet-forming type of collagen found in basement membranes where it serves a critical scaffolding function. In mammals, six proteins make up the type IV collagen family with the distribution of family members being tissue-specific. Structurally, three collagen IV alpha chains assemble to form a flexible heterotrimeric protomer that can self-assemble into network polymers.
Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain . Mutations in COL4A5 are associated with Alport syndrome.
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