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C5688 Sigma

Complement factor D from human plasma

90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)

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Description

Analysis Note

Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2

Biochem/physiol Actions

Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Application

Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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