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C5723 Sigma

Anti-Cytochrome c antibody produced in sheep

whole antiserum

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins,
species reactivity   rat, human, rabbit, canine
application(s)   immunoprecipitation: suitable
  indirect immunofluorescence: suitable
  western blot: 1:5,000 using MCF-7, Rat-1, MDCK or Jurkat cell extracts
clone   polyclonal
antibody form   whole antiserum
mol wt   antigen mol wt 14.4 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CYCS(54205)
rat ... Cycs(25309)
biological source   sheep
conjugate   unconjugated

Description

Immunogen

rabbit cytochrome c

Antigen Background

Cytochrome c is an electron transport protein released from mitochondria as an early committed event in apoptosis. Cytochrome c and dATP are cofactors for the mammalian apoptosome, which is composed of Apaf-1, Bcl-2, and procaspase 9. When caspase 9 is activated, activation of other caspases follow including the death protease caspase 3. The release of cytochrome c is inhibited by the presence of Bcl-2 on these organelles preventing the initiation of apoptosis. In cells induced by several apoptotic agents (such as UV irradiation, staurosporine, and overexpression of Bax), caspase inhibitors do not prevent cytochrome c release.

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