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C5813 Sigma

Complement factor H from human plasma

1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)

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Description

Biochem/physiol Actions

C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.

Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Application

Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.

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Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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