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C5848 Sigma

Monoclonal Anti-CCR-2 antibody produced in mouse

clone 48607.121, purified immunoglobulin, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokine Receptors, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   flow cytometry: suitable
clone   48607.121, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2b
storage temp.   −20°C
Gene Information   human ... CCR2(1231)
mouse ... Ccr2(12772)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human CCR-2 transfected NSO mouse myeloma cells.

General description

C-C chemokine receptor type 2 (CCR-2) is a protein that belongs to chemokine cytokine family and is expressed mainly on monocytes. It has a crucial role in activation and migration of leukocytes. It also facilitates in the pathogenesis of vasculitis in Kawasaki disease (KD) . Monoclonal Anti-CCR-2 antibody can be used in flow cytometry for the Identification of human CCR-2. Mouse anti-CCR-2 antibody reacts specifically with CCR-2 transfected cells but not with the parent cell line. No cross reactivity has been observed with CCR-5 transfected cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Specificity

The antibody reacts with CCR-2 transfectant cells and not the parent cell line. It shows no cross-reactivity with CCR-5 transfectant cells.

Preparation Note

Purified using protein G.

Application

Monoclonal Anti-CCR-2 antibody can be used as a positive control in immunohistochemical staining.

Price and Availability


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