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C5848 Sigma

Monoclonal Anti-CCR-2 antibody produced in mouse

clone 48607.121, purified immunoglobulin, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokine Receptors, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   flow cytometry: suitable
clone   48607.121, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2b
storage temp.   −20°C
Gene Information   human ... CCR2(1231)
mouse ... Ccr2(12772)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human CCR-2 transfected NSO mouse myeloma cells.

General description

C-C chemokine receptor type 2 (CCR-2) is a protein that belongs to chemokine cytokine family and is expressed mainly on monocytes. It has a crucial role in activation and migration of leukocytes. It also facilitates in the pathogenesis of vasculitis in Kawasaki disease (KD) . Monoclonal Anti-CCR-2 antibody can be used in flow cytometry for the Identification of human CCR-2. Mouse anti-CCR-2 antibody reacts specifically with CCR-2 transfected cells but not with the parent cell line. No cross reactivity has been observed with CCR-5 transfected cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Specificity

The antibody reacts with CCR-2 transfectant cells and not the parent cell line. It shows no cross-reactivity with CCR-5 transfectant cells.

Preparation Note

Purified using protein G.

Application

Monoclonal Anti-CCR-2 antibody can be used as a positive control in immunohistochemical staining.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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