|Related Categories||Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, C-CH, Cell Biology,|
|impurities||~0.5 mol/mol water|
|solubility||DMSO: >10 mg/mL|
|Gene Information||human ... RARA(5914), RARB(5915), RARG(5916)|
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Teratogens, Transcription, Ubiquitinations, Vitamins
Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells. Sun, S.Y., et al. Mol. Pharmacol. 58, 508-514, (2000)
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