C6012 Sigma




Related Categories Biochemicals and Reagents, Cholesterol and Derivatives, Lipids, Sterol Lipids
assay   ~95%
mp   78-80 °C(lit.)
storage temp.   −20°C


Preparation Note

Cholesta-3,5-diene yields clear, colorless solution in chloroform at 50 mg/ml.


Cholesta-3,5-diene was used as standard in HPLC in quality analysis of different types of olive oils1 and edible fats.2

Biochem/physiol Actions

Cholesta-3,5-diene is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis.3 The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation.4 Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.3

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