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C6013 Sigma

Cholesteryl hemisuccinate tris salt

anionic detergent

Synonym: 3β-Hydroxy-5-cholestene 3-hemisuccinate, 5-Cholesten-3β-ol 3-hemisuccinate, CHEMS, CHS, Cholesteryl hydrogen succinate

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Properties

InChI Key   SLDYONDUXRBLLR-XTCKSVDZSA-N
storage temp.   −20°C

Description

Packaging

5, 25 g in poly bottle

Preparation Note

Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.

Application

Cholesteryl hemisuccinate (CHEMS) is a membrane stabilizer for liposomes. CHEMS improves the stability of membrane protein synaptogyrin-1. It has been used as a component of a folate-modified self-microemulsifying drug delivery system. Detergent blends with n-dodecyl β-D-maltoside (DDM) and CHEMS has been used to solubilize erythrocyte ghosts and chemokine receptor CCR1.

Cholesteryl succinate tris salt was used to prepare solubilization buffer for glucan synthase assay and immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.Cholesteryl hemisuccinate (CHEMS) is a membrane stabilizer for liposomes. CHEMS improves the stability of membrane protein synaptogyrin-1. It has been used as a component of a folate-modified self-microemulsifying drug delivery system. Detergent blends with n-dodecyl β-D-maltoside (DDM) and CHEMS has been used to solubilize erythrocyte ghosts and chemokine receptor CCR1.

Biochem/physiol Actions

Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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