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C6143 Sigma

Chlorhexidine diacetate salt hydrate

bis(biguanide) antimicrobial

Synonym: 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   WDRFFJWBUDTUCA-UHFFFAOYSA-N
solubility   ethanol: soluble50 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria

Description

Biochem/physiol Actions

Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective against both Gram-positive and Gram-negative bacteria. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Packaging

25, 100 g in poly bottle

Application

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has been used to study the inactivation of HIV and the immobilization of sperm. It was used to study effective skin antisepsis and disinfection of medical devices as well as the effects of antimicrobials on dental plaque.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
DU1930000
Protocols & Articles
Peer-Reviewed Papers
15

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