C6143 Sigma

Chlorhexidine diacetate salt hydrate

bis(biguanide) antimicrobial

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Synonym: 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

Description

Biochem/physiol Actions

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. It′s mechanism of action involves destabilization of the outer bacterial membrane.

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Application

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has been used to study the inactivation of HIV and the immobilization of sperm 1. It is used to study effective skin antisepsis and disinfection of medical devices 2 as well as the effects of antimicrobials on dental plaque3.

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