|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling and Neuroscience,|
|color||red to brown|
|solubility||DMF: soluble1 mg/mL|
|DMSO: soluble1 mg/mL|
|ethanol: soluble1 mg/mL|
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.
Certificate of Analysis
Certificate of Origin
Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death. Ozaki, I., et al. J. Biol. Chem. 274, 5310-5317, (1999)
Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Begemann, M., et al. Anticancer Res. 18, 3139-3152, (1998)
PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Ketsawatsomkron P, Lorca RA, Keen HL, et al. Circ. Res. 111(11), 1446-58, (2012)
Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. David M, Macías Á, Moreno C, et al. J. Biol. Chem. 287(25), 21416-28, (2012)
Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels. Vetri F, Xu H, Paisansathan C, et al. Am. J. Physiol. Heart Circ. Physiol. 302(6), H1274-84, (2012)
Rosiglitazone, a PPAR-γ agonist, inhibits VEGF secretion by peripheral blood mononuclear cells and ROS production by human leukocytes. Mattos RT, Bosco AA, and Nogueira-Machado JA Inflamm. Res. 61(1), 37-41, (2012)
Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C. Olavarría VH, Figueroa JE, and Mulero V Dev. Comp. Immunol. 36(1), 216-21, (2012)
Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes. Lemoine S, Zhu L, Buléon C, et al. Br. J. Anaesth. 107(4), 510-8, (2011)
Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB. Inoue T, Kobayashi K, Inoguchi T, et al. J. Biol. Chem. 286(37), 32045-53, (2011)
Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. Rouette A, Parent S, Girouard J, et al. Int. J. Cancer 130(8), 1755-67, (2012)
Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Martín F, Mora L, Laorden M, et al. Br. J. Pharmacol. 163(4), 857-75, (2011)
Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Singh J, Maxwell PJ, and Rattan S Am. J. Physiol. Gastrointest. Liver Physiol. 301(2), G317-25, (2011)
Interpretation of the effects of protein kinase C inhibitors on human UDP-glucuronosyltransferase 1A (UGT1A) proteins in cellulo. Abe Y, Fujiwara R, Oda S, et al. Drug Metab. Pharmacokinet. 26(3), 256-65, (2011)
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries. Robles JC, Sturek M, Parker JL, et al. Am. J. Physiol. Heart Circ. Physiol. 300(4), H1201-9, (2011)
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