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C6344 Sigma

Monoclonal Anti-Connexin-32 antibody produced in mouse

clone CXN-32, ascites fluid, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
species reactivity   rat, human, mouse
application(s)   immunohistochemistry (frozen sections): suitable
  indirect ELISA: suitable
  microarray: suitable
  western blot: 1:1,000 using a mouse whole brain extract
clone   CXN-32, monoclonal
antibody form   ascites fluid
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 27 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GJB1(2705), GJB2(2706)
mouse ... Gjb1(14618)
rat ... Gja1(24392), Gjb1(29584)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic connexin-32 peptide (amino acids 105-123).

Application

Monoclonal Anti-Connexin-32 antibody produced in mouse is suitable for the following applications:
• Immunohistochemistry
• Indirect ELISA
• Microarray
• Western blotting

Biochem/physiol Actions

Connexins belong to the gap junction protein family. In humans, connexin is encoded by GJB1 (gap junction protein, β 1) gene. The gap junction proteins connexin32 (Cx32), Cx37, Cx40 and Cx43 are expressed in endothelial cells and regulate vascular functions involving inflammation. The endothelial Cx32 positively regulates angiogenesis by enhancing endothelial cell tube formation and cell migration. CX32 mutation is associated with cognitive impairment and a differential degree of peripheral nerve involvement.

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