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C6598 Sigma

Monoclonal Anti-CXCR4 (Fusin) antibody produced in mouse

clone 44716, purified immunoglobulin, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells, Antibodies for Stem Cell Biology,
species reactivity   human, feline
application(s)   flow cytometry: suitable
  immunohistochemistry: suitable
  neutralization: suitable
clone   44716, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2b
storage temp.   −20°C
Gene Information   human ... CXCR4(7852)
mouse ... Cxcr4(12767)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human CXCR4 transfected mouse 3T3 cells.

General description

The antibody will neutralize human cell surface CXCR4 mediated bioactivity. It reacts with human CXCR4 transfectant cells, but not the parent cell line. The antibody will not react with rat CXCR4.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Biochem/physiol Actions

CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.

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