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C6680 Sigma

Monoclonal Anti-HNK-1/N-CAM (CD57) antibody produced in mouse

clone VC1.1, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-CD57, Anti-N-CAM, Monoclonal Anti-HNK-1

Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
species reactivity   feline, human, mouse, rat
application(s)   flow cytometry: 5 μL using 1 × 106 cells
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
clone   VC1.1, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgM
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... B3GAT1(27087)
mouse ... B3gat1(76898)
rat ... B3gat1(117108)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

A homogenate of cat primary visual cortex (area 17)

Antigen Background

CD57/HNK-1 is expressed on a subpopulation of 15-20% of peripheral blood mononuclear cells, about 60% of NK active cells and on a subset of T cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Specificity

Recognizes the CD57/HNK-1 human myeloid cell associated surface glycoprotein. The epitope recognized is an N-linked carbohydrate which is present in a variety of glycoproteins and in some glycolipids. It is resistant to formalin fixation and paraffin embedding. VC1.1 antibody and the HNK-1 (Leu7) antibody inhibit the binding of each other. The antibody recognizes myelin associated glycoprotein in some species and a high molecular weight chondroitin sulphate proteoglycan.
5th Workshop: code no. NK 67

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