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C6747 Sigma

Anti-CDX2 (71-83) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-CDX-3, Anti-CDX3, Anti-Homeobox protein CDX-2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies to Transcription Factors, CB - E999, CDH-CDY,
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~34 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CDX2(1045)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 71-83 of human CDX2

General description

Caudal type homeobox 2 (CDX-2) gene encodes the CDX-2 protein which is a transcription factor expressed in the nuclei of intestinal epithelial cells. CDX2 is a master transcriptional regulator of intestinal cell differentiation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CDX2 (71-83) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000

Biochem/physiol Actions

Caudal type homeobox 2 (CDX-2) regulates gene expression through transcription and pre-mRNA processing. It appears to induce the transformation of the normal oesophageal mucosa to cardia type and is differentiated to an intestinal type under the influence of gastro-oesophageal reflux disease. CDX2 can act as an early marker for Barrett′s oesophagus in the absence of goblet cells as expression. It also acts as a marker to indicate colorectal lineage in adenocarcinomas. CDX2 is expressed in pancreas and can be used as a prognostic marker for Pancreatic ductal adenocarcinoma (PDAC). It plays a key role in the differentiation of Caco-2 cells which is a colon carcinoma derived cell line that undergoes spontaneous differentiation.

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