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C6762 Sigma

Cytochalasin B from Drechslera dematioidea

≥98% (HPLC), powder

Synonym: Phomin

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Properties

Related Categories Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,
InChI Key   GBOGMAARMMDZGR-TYHYBEHESA-N
Quality Level   PREMIUM
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: soluble10 mg/mL
Mode of action   DNA synthesis | interferes
storage temp.   −20°C

Description

Biochem/physiol Actions

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Packaging

1, 5, 10, 25, 50 mg in serum bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGII
WGK Germany 
3
RTECS 
RO0205000
Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Biofiles, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Support, Transcription

Peer-Reviewed Papers
15

References

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