|Related Categories||3.4.x.x Peptidases, 3.x.x.x Hydrolases, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents,|
|shipped in||dry ice|
|Gene Information||human ... CTSL1(1514)|
One unit will hydrolyze 1.0 μmole of Z-Phe-Arg-AFC per minute at pH 5.5 at 25 °C.
Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl.
The most powerful of the lysosomal proteinases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.
Customers Also Viewed
lyophilized powder, ≥10 units/mg protein
buffered aqueous solution, ≥2,000 units/mg protein (E
recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE)
From our library of Related Content, Sigma-Aldrich presents Enzyme Explorer: the most comprehensive source of enzymes, substrates, activators, & inhibitors.
Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. Mallinson JE, Constantin-Teodosiu D, Glaves PD, et al. J. Physiol. 590(Pt 24), 6389-402, (2012)
TGF-β signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells. Yin M, Soikkeli J, Jahkola T, et al. Am. J. Pathol. 181(6), 2202-16, (2012)
The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide. Kanbak G, Kartkaya K, Ozcelik E, et al. Gene 512(2), 492-5, (2013)
The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development. Morin V, Sanchez-Rubio A, Aze A, et al. PLoS ONE 7(11), e46850, (2012)
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Arampatzidou M, Schütte A, Hansson GC, et al. Biol. Chem. 393(12), 1391-403, (2012)
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. Chavarria GE, Horsman MR, Arispe WM, et al. Eur. J. Med. Chem. 58, 568-72, (2012)
Cloning, heterologous expression, and enzymatic characterization of cathepsin L from starfish (Asterina pectinifera). Lee AR, Bak HJ, Kim NY, et al. Biosci. Biotechnol. Biochem. 76(12), 2342-6, (2012)
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. Joseph LJ, Chang LC, Stamenkovich D, et al. J. Clin. Invest. 81(5), 1621-9, (1988)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?