Synonym: Cefotaxim sodium salt
|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
|color||white to light yellow|
|solubility||H2O: soluble (aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.)|
|suitability||plant cell culture tested|
Broad spectrum third generation cephalosporin antibiotic.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes.
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Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P342 + P311|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||42/43|
|Safety Statements (Europe)||22-36/37|
1Application Key: CC = Callus Culture; PR = plant regeneration; EC = cotyledon, hypocotyl, or leaf disc culture; TS = transformant selection; SE = somatic embryogenesis; SSC = stem selection culture;...
Keywords: Antibiotics, Cell culture
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
Cefotaxime-heparin lock prophylaxis against hemodialysis catheter-related sepsis among Staphylococcus aureus nasal carriers. Saxena AK, Panhotra BR, Al-hafiz AA, et al. Saudi J. Kidney Dis. Transpl. 23(4), 743-54, (2012)
Prevalence and molecular characterization of extended-spectrum-β-lactamase-producing Enterobacteriaceae in a pediatric patient population. Chandramohan L and Revell PA Antimicrob. Agents Chemother. 56(9), 4765-70, (2012)
An RP-HPLC-UV method with SPE for cefotaxime in all-in-one total parenteral nutritional admixtures: application to stability studies. Iqbal MS, Bahari MB, Darwis Y, et al. J. AOAC Int. 96(2), 290-4, (2013)
AFM probing the mechanism of synergistic effects of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) with cefotaxime against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. Cui Y, Kim SH, Kim H, et al. PLoS ONE 7(11), e48880, (2012)
β-Lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives. Mehta S, Singh C, Plata KB, et al. Antimicrob. Agents Chemother. 56(12), 6192-200, (2012)
Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms. Yoshida H, Kawai F, Obayashi E, et al. J. Mol. Biol. 423(3), 351-64, (2012)
Enhanced Iron and Zinc Accumulation in Genetically Engineered Pineapple Plants Using Soybean Ferritin Gene. Mhatre M, Srinivas L, Ganapathi TR. Biol. Trace Elem. Res., (2011)
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