• USA Home
  • C7039 - Cefotaxime sodium salt

EMAIL THIS PAGE TO A FRIEND

C7039 Sigma

Cefotaxime sodium salt

plant cell culture tested, BioReagent, powder

Synonym: Cefotaxim sodium salt

Purchase

Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
product line   BioReagent
form   powder
color   white to light yellow
solubility   H2O: soluble (aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.)
suitability   plant cell culture tested
Featured Industry   Agriculture
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Additional Products to Explore

Carbenicillin disodium salt

89.0-100.5% anhydrous basis

Ceftazidime hydrate

90.0-105.0%

Chloramphenicol

≥98% (HPLC)

Ciprofloxacin

≥98.0% (HPLC)

Rifampicin

≥97% (HPLC), powder

Customers Also Viewed

Cefotaxime sodium

European Pharmacopoeia (EP) Reference Standard

Cefotaxime sodium

United States Pharmacopeia (USP) Reference Standard

Cefotaxime sodium salt

potency: 916-964 μg per mg

Ceftazidime hydrate

90.0-105.0%

Ceftriaxone disodium salt hemi(heptahydrate)

third-generation cephalosporin antibiotic

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
2
RTECS 
XI0250000

Protocols & Articles

Related Content

Antibiotic Selection Guide

1Application Key: CC = Callus Culture; PR = plant regeneration; EC = cotyledon, hypocotyl, or leaf disc culture; TS = transformant selection; SE = somatic embryogenesis; SSC = stem selection culture;...
Keywords: Antibiotics, Cell culture

Plant Tissue Culture Products | Agriculture

Our combination of quality products, services and global business capabilities help you to maintain reagent consistency while ensuring suitability. Sigma-Aldrich allows you to standardize reagents ac...
Keywords: Antibiotics, Cell culture, Culture media, Gas chromatography, High performance liquid chromatography, Mass spectrometry, Plant biotechnology, Vitamins, transformation

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Enhanced Iron and Zinc Accumulation in Genetically Engineered Pineapple Plants Using Soybean Ferritin Gene. Mhatre M, Srinivas L, Ganapathi TR. Biol. Trace Elem. Res., (2011)

Development of genotype-independent regeneration system for transformation of rice (Oryza sativa ssp. indica). Yookongkaew N, Srivatanakul M, Narangajavana J. J. Plant Res. 120, 237-245, (2007)

Loading...


In vitro plant regeneration and genetic transformation of Dichanthium annulatum. Kumar J, Shukla SM, Bhat V, et al. DNA Cell. Biol. 24, 670-679, (2005)

Loading...


Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

Loading...


Quantifying the adaptive potential of an antibiotic resistance enzyme. Schenk MF, Szendro IG, Krug J, et al. PLoS Genet. 8(6), e1002783, (2012)

Loading...


Carriage and fecal counts of cefotaxime M-producing Escherichia coli in pigs: a longitudinal study. Hansen KH, Damborg P, Andreasen M, et al. Appl. Environ. Microbiol. 79(3), 794-8, (2013)

Loading...


De novo aneurysm on the posterior cerebral artery: a case report and literature review. Chankaew E, Sitthinamsuwan B, Srirabheebhat P, et al. J. Med. Assoc. Thai. 95(12), 1613-8, (2012)

Loading...


[Generalized cutaneous candidiasis in newborn at term]. El Ahmed HH, Cañadas-De la Fuente GA, Fernández-Castillo R, et al. Biomedica. 32(2), 170-3, (2012)

Loading...


Evaluation of different therapeutic approaches for spontaneous bacterial peritonitis. Abd Elaal MM, Zaghloul SG, Bakr HG, et al. Arab J. Gastroenterol. 13(2), 65-70, (2012)

Loading...


Cefotaxime-heparin lock prophylaxis against hemodialysis catheter-related sepsis among Staphylococcus aureus nasal carriers. Saxena AK, Panhotra BR, Al-hafiz AA, et al. Saudi J. Kidney Dis. Transpl. 23(4), 743-54, (2012)

Loading...


Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Helaine S, Cheverton AM, Watson KG, et al. Science 343(6167), 204-8, (2014)

Loading...


Cefotaxime prevents microbial contamination and improves microspore embryogenesis in wheat and triticale. Asif M, Eudes F, Randhawa H, et al. Plant Cell Rep. 32(10), 1637-46, (2013)

Loading...


β-Lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives. Mehta S, Singh C, Plata KB, et al. Antimicrob. Agents Chemother. 56(12), 6192-200, (2012)

Loading...


AFM probing the mechanism of synergistic effects of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) with cefotaxime against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. Cui Y, Kim SH, Kim H, et al. PLoS ONE 7(11), e48880, (2012)

Loading...


Extended spectrum ß-lactamase- and constitutively AmpC-producing Enterobacteriaceae on fresh produce and in the agricultural environment. Blaak H, van Hoek AH, Veenman C, et al. Int. J. Food Microbiol. 168-169, 8-16, (2014)

Loading...


Prevalence and molecular characterization of extended-spectrum-β-lactamase-producing Enterobacteriaceae in a pediatric patient population. Chandramohan L and Revell PA Antimicrob. Agents Chemother. 56(9), 4765-70, (2012)

Loading...


Narrow vs broad-spectrum antimicrobial therapy for children hospitalized with pneumonia. Williams DJ, Hall M, Shah SS, et al. Pediatrics 132(5), e1141-8, (2013)

Loading...


Prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae in meat products sold in Navarra, Spain. Ojer-Usoz E, González D, Vitas AI, et al. Meat Science 93(2), 316-21, (2013)

Loading...


Evaluation of MicroScan WalkAway and Vitek 2 for determination of the susceptibility of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates to cefepime, cefotaxime and ceftazidime. Jang W, Park YJ, Park KG, et al. J. Antimicrob. Chemother. 68(10), 2282-5, (2013)

Loading...


Transcriptome analysis and physiology of Bifidobacterium longum NCC2705 cells under continuous culture conditions. Mozzetti V, Grattepanche F, Moine D, et al. Benef. Microbes 3(4), 261-72, (2012)

Loading...


Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report. van Dam AP, van Ogtrop ML, Golparian D, et al. Sex. Transm. Infect. 90(7), 513-4, (2014)

Loading...


The Escherichia coli phylogenetic group B2 with integrons prevails in childhood recurrent urinary tract infections. Kõljalg S, Truusalu K, Stsepetova J, et al. APMIS 122(5), 452-8, (2014)

Loading...


Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms. Yoshida H, Kawai F, Obayashi E, et al. J. Mol. Biol. 423(3), 351-64, (2012)

Loading...


Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). Yee SW, Nguyen AN, Brown C, et al. J. Pharm. Sci. 102(9), 3451-7, (2013)

Loading...


A cluster of meningococcal disease caused by rifampicin-resistant C meningococci in France, April 2012. Mounchetrou Njoya I, Deghmane A, Taha M, et al. Euro Surveill. 17(34), (2012)

Loading...


Regional outbreak of CTX-M-2 β-lactamase-producing Proteus mirabilis in Japan. Nakano R, Nakano A, Abe M, et al. J. Med. Microbiol. 61(Pt 12), 1727-35, (2012)

Loading...


Review of cefotaxime sodium for surgical prophylaxis. A model for the evolution toward single-dose or short-course cost-effective regimens. Jones RN Diagn. Microbiol. Infect. Dis. 13(4), 317-27, (1990)

Loading...


Extended-spectrum β-lactamases in Enterobacteriaceae isolated in Brazil carry distinct types of plasmid-mediated quinolone resistance genes. Viana AL, Cayô R, Avelino CC, et al. J. Med. Microbiol. 62(Pt 9), 1326-31, (2013)

Loading...


Neuroborreliosis presenting as acute disseminated encephalomyelitis. Rocha R, Lisboa L, Neves J, et al. Pediatr. Emerg. Care 28(12), 1374-6, (2012)

Loading...


An RP-HPLC-UV method with SPE for cefotaxime in all-in-one total parenteral nutritional admixtures: application to stability studies. Iqbal MS, Bahari MB, Darwis Y, et al. J. AOAC Int. 96(2), 290-4, (2013)

Loading...


Spontaneous bacterial peritonitis caused by Listeria monocytogenes: a case report and literature review. Cardoso C, Cremers I, and Oliveira AP Ann. Hepatol. 11(6), 955-7, (2012)

Loading...


Cefotaxime-eluting covered self-expandable stents in a canine biliary model: scanning electron microscopic study of biofilm formation. Gwon DI, Lee SS, and Kim EY Acta radiol. 53(10), 1127-32, (2012)

Loading...


'Leptotrichia amnionii', a newly reported cause of early onset neonatal meningitis. Decroix V, Goudjil S, Kongolo G, et al. J. Med. Microbiol. 62(Pt 5), 785-8, (2013)

Loading...


Streptococcus pneumoniae: an unusual pathogen in neonatal sepsis of vertical transmission. Hermoso Torregrosa C, Carrasco Zalvide M, and Ferrer Castillo MT Arch. Bronconeumol. 48(11), 425-6, (2012)

Loading...


[Dermohypodermitis and gut translocation Escherichia coli septicemia in a newborn infant]. Gouache E, Chantier E, Hubert N, et al. Arch. Pediatr. 20(1), 26-9, (2013)

Loading...


83-year-old man with abdominal swelling and lower extremity edema. Saffouri GB and Wittich CM Mayo Clin. Proc. 88(10), e115-8, (2013)

Loading...


Human infection of Salmonella matadi in Korea. Lee DY and Kang Y Yonsei Med. J. 54(5), 1297-8, (2013)

Loading...


[Streptococcus suis type 2: emerging pathogen producer of meningitis]. Baena IM, Fernández C, Sánchez J, et al. Rev. Esp. Quimioter. 25(4), 293-4, (2012)

Loading...


[Pneumonia due to Yersinia enterocolitica]. Jarrot PA, Mahmoudi R, Novella JL, et al. Med. Mal. Infect. 43(1), 38-9, (2013)

Loading...


Brain microdialysis distribution study of cefotaxime in a patient with traumatic brain injury. Frasca D, Dahyot-Fizelier C, Couet W, et al. Br. J. Anaesth. 109(5), 830-1, (2012)

Loading...


Coincident diagnosis of a pulmonary abscess and ascaris lumbricoides infection: a possible causal connection? Gerber A, Franz C, and Mainz JG Klin. Padiatr. 224(7), 469-70, (2012)

Loading...


Merck 14,1933

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?