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C7055 Sigma

Monoclonal Anti-Calmodulin antibody produced in mouse

clone 2D1+6D4+1F11, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Intracellular Calcium Signaling, Antibodies to Calcium-Associated Proteins,
species reactivity   chicken, rat, Dictyostelium discoideum, bovine
application(s)   microarray: suitable
  western blot: 1:100 using a bovine brain calmodulin preparation
clone   2D1+6D4+1F11, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide as preservative
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Calm1(24242)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

A preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.

Specificity

These antibodies are directed against different epitopes within the calmodulin molecule.

Application

Monoclonal Anti-Calmodulin antibody produced in mouse is suitable for microarray and western blotting at a dilution of 1:100 using a bovine brain calmodulin preparation.

Biochem/physiol Actions

Calmodulin 1 is a protein encoded by the CALM1 gene in humans. It is one of the most well characterized proteins and is used as a model system for calcium binding and large-scale protein conformational changes. Acts as a sensor protein that takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. It binds calcium ions during induction of intracellular signaling and is involved in silencing of calcium signal through activation of plasma membrane Ca2+-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels like voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors and calcium channels dependent on cyclic nucleotides or in endoplasmic reticulum.

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