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C7089 Sigma

Monoclonal Anti-Cdk7/CAK antibody produced in mouse

clone MO-1.1, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human
application(s)   immunocytochemistry: suitable
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  microarray: suitable
  western blot: 1:50,000 using a cultured human cell line extract
clone   MO-1.1, monoclonal
antibody form   ascites fluid
isotype   IgG2b
mol wt   antigen mol wt 40 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CDK7(1022)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human Cdk7 protein.

General description

Cell division protein kinase 7 is an enzymes encoded by the CDK7 gene in humans. The protein belongs to cyclin-dependent protein kinase (CDK) family. CAK is a CDK-cyclin complex implicated in the control of multiple cell cycle transitions. The structure of CDK7 facilitates the inhibitors with differential specificity for the different CDKs and can be used in different biological processes.

Specificity

The antibody reacts specifically with Cdk7 (40 kDa catalytic subunit of Cdk activating kinase).

Application

Monoclonal Anti-Cdk7/CAK antibody produced in mouse is suitable for the following applications:
• Immunocytochemistry
• Immunohistochemistry (frozen sections)
• Immunoprecipitation
• Microarray
• Western blotting at a dilution of 1:50,000 using a cultured human cell line extract

Biochem/physiol Actions

Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is involved in activation and phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell cycle. It is required for cell cycle progression and it could be a target for cancer therapy. CAK plays a central role in regulation of messenger RNA synthesis by either inhibition of RNA polymerase II-catalyzed transcription or stimulation of transcription through association with basal transcription repair factor IIH. Phosphorylation by the CDK-activating kinase (CAK) is required for the activation of cyclin-dependent kinases.

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