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  • C7122 - Anti-CDX4 (231-245) antibody produced in rabbit

C7122 Sigma

Anti-CDX4 (231-245) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Homeobox protein CDX-4



Related Categories Alphabetical Index, Antibodies, Antibodies to Transcription Factors, CB - E999, CDH-CDY,
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~30 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CDX4(1046)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 231-245 of human CDX4

General description

The gene CDX4 (Caudal type homeobox 4) is mapped to human chromosome Xq13.2. It belongs to CDX family of proteins.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-CDX4 (231-245) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Caudal type homeobox 4 (CDX4) is a key regulator of the HOX (Homeobox proteins) family. CDX4 regulates expression of HOX genes, including HOXB3, HOXB4 and HOXA7-11. In zebrafish, absence of CDX4 disrupts hematopoiesis and impairs expression of specific HOX genes. Mice with overexpressing CDX4-bone marrow develops acute myeloid leukemia over time. HOXA10 controls CDX4 transcription either directly or through FGF2 (Fibroblast growth factor 2)-induced activation of β-catenin.

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