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  • C7159 - Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse

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C7159 Sigma

Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse

clone K4.62, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
species reactivity   human
application(s)   indirect immunofluorescence: 1:20 using frozen human tissue sections
clone   K4.62, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KRT19(3880)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

cytoskeletal proteins from the cultured human breast carcinoma cell line MCF-7

Specificity

Reacts with cytokeratin polypeptide 19. The antibody labels the basal layer of non-keratinizing epithelium, metaplastic epithelium of the cervix, simple epithelium, transitional epithelium, squamous cell carcinomas and adenocarcinomas expressing cytokeratin 19.

Application

Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:20 using frozen human tissue sections.

Biochem/physiol Actions

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

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