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C7420 Sigma

μ-Conotoxin GIIIA

≥90% (HPLC)

  • CAS Number 129129-65-3

  • Empirical Formula (Hill Notation) C100H170N38O32S6

  • Molecular Weight 2609.05

  • Popular Documents:  Datasheet (PDF)  

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Properties

assay   ≥90% (HPLC)
composition   Peptide content, ~60%
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Hyp-Gln-Arg-Cys-Cys-Ala-NH2 [Disulfide Bridges: undefined]

Biochem/physiol Actions

Selective blocker of voltage-dependent Na+ channels which exhibits channel binding kinetics similar to those of tetrodotoxin and saxitoxin, but possesses a >1,000 fold selectivity for muscle versus neuronal Na+ channels; originally isolated from the venom of the marine snail Conus geographus L.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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