|Related Categories||Amino Acid, Amino Acid Library, Cell Biology, Metabolic Libraries, Metabolic Pathways,|
10, 50, 250 mg in poly bottle
L-Cystathionine is an intermediate in the biosynthesis of the amino acid -L cysteine. L-Cystathionine is used as a substrate to differentiate and analyze cystathionine gamma-lyase(s).
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C7505.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death. Maclean KN, Greiner LS, Evans JR, et al. J. Biol. Chem. 287(38), 31994-2005, (2012)
Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses. Vuillefroy de Silly R, Coulon F, Poirier N, et al. Blood 119(11), 2633-43, (2012)
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Dekan Z, Vetter I, Daly NL, et al. J. Am. Chem. Soc. 133(40), 15866-9, (2011)
RP-HPLC method for quantitative determination of cystathionine, cysteine and glutathione: An application for the study of the metabolism of cysteine in human brain. Bronowicka-Adamska P, Zagajewski J, Czubak J, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(21), 2005-9, (2011)
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Maclean, K.N., et al. Mol. Genet. Metab. 101, 153-62, (2010)
Differential response of methionine metabolism in two grain legumes, soybean and azuki bean, expressing a mutated form of Arabidopsis cystathionine γ-synthase. Hanafy MS, Rahman SM, Nakamoto Y, et al. J. Plant Physiol. 170(3), 338-45, (2013)
Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women. Lamers Y, Coats B, Ralat M, et al. J. Nutr. 141(5), 835-42, (2011)
Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects. Herrmann W, Schorr H, Bodis M, et al. Eur. J. Clin. Invest. 30(12), 1083-9, (2000)
The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Selley ML, Close DR, and Stern SE Neurobiol. Aging 23(3), 383-8, (2002)
Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Raskind MA, Peskind ER, Holmes C, et al. Biol. Psychiatry 46(6), 756-65, (1999)
Similarity of the oxidation products of L-cystathionine by L-amino acid oxidase to those excreted by cystathioninuric patients. Ricci G, Santoro L, Achilli M, et al. J. Biol. Chem. 258(17), 10511-7, (1983)
Failure to detect beta-leucine in human blood or leucine 2,3-aminomutase in rat liver using capillary gas chromatography-mass spectrometry. Stabler SP, Lindenbaum J, and Allen RH J. Biol. Chem. 263(12), 5581-8, (1988)
Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Shaw W Nutr. Neurosci. 13(3), 135-43, (2010)
Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Guo K and Li L Anal. Chem. 81(10), 3919-32, (2009)
Determination of cystathionine and perhydro-1,4-thiazepine-3,5-dicarboxylic acid in the urine of a patient with cystathioninuria using column liquid chromatography-mass spectrometry. Sugahara K, Ohta J, Takemura M, et al. J. Chromatogr. A 579(2), 318-23, (1992)
Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Jia JP, Jia JM, Zhou WD, et al. Chin. Med. J. 117(8), 1161-4, (2004)
Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. Serot JM, Barbé F, Arning E, et al. J. Neurol. Neurosurg. Psychiatr. 76(11), 1585-7, (2005)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?