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C7522 Sigma

Calcium Ionophore A23187

≥98% (TLC), powder

Synonym: Antibiotic A 23187, Calimycin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
Quality Level   PREMIUM
assay   ≥98% (TLC)
form   powder
color   white to light yellow
solubility   ethanol: soluble5 mg/mL (with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)
  DMSO: soluble50 mg/mL (with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)
storage temp.   2-8°C

Description

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3
RTECS 
DM4676000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

NFATc1 Mediates Toll-like Receptor-independent Innate Immune Responses During Trypanosoma Cruzi Infection. Kayama, H., et al. PLoS Pathog. 5, e1000514, (2009)

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Diarylheptanoid From Pleuranthodium Racemigerum With In Vitro Prostaglandin E(2) Inhibitory And Cytotoxic Activity. Wohlmuth, H., et al. J. Nat. Prod. 73, 743-6, (2010)

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Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. Kauffman, R.F., et al. J. Biol. Chem. 255, 2735-2739, (1980)

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Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Markram, H., and Segal, M. Brain Res. 540, 322-324, (1991)

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Nitric oxide as a signal in blood vessels. Knowles, R.G., and Moncada, S. Trends Biochem. Sci. 17, 399-402, (1992)

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Biological applications of ionophores. Pressman, B.C. Annu. Rev. Biochem. 45, 501, (1976)

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Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. Yamada, P., et al. J. Neurophysiol. 116, 279-87, (2008)

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Chemical activation of in vitro matured dromedary camel (Camelus dromedarius) oocytes: optimization of protocols. Wani, N.A. Ther. Drug Monit. 69, 591-602, (2008)

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Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9. Bode, G., et al. J. Bacteriol. 283, 31776-84, (2008)

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TgICMAP1 is a novel microtubule binding protein in Toxoplasma gondii. Heaslip, A.T., et al. PLoS Biol. 4, e7406, (2009)

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Echinophilic Proteins Stomatin, Sorcin, And Synexin Locate Outside GangliosideM1 (GM1) Patches In The Erythrocyte Membrane. Mrówczyńska, L., et al. Biochem. Biophys. Res. Commun. 401, 396-400, (2010)

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In Vitro And In Vivo Developmental Competence Of Dromedary (Camelus Dromedarius) Oocytes Following In Vitro Fertilization Or Parthenogenetic Activation. Khatir, H., et al. Anim. Reprod. Sci. 113, 212-9, (2009)

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Whole blood aggregation and coagulation in db/db and ob/ob mouse models of type 2 diabetes. Henry, M.L., et al. Blood Coag. Fibrinolysis 19, 124-34, (2008)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Selective triggering of platelet apoptosis, platelet activation or both. Gyulkhandanyan AV, Mutlu A, Freedman J, et al. Br. J. Haematol. 161(2), 245-54, (2013)

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Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, Fujii T, Imao T, et al. J. Biol. Chem. 288(19), 13305-16, (2013)

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Cooperation between β- and γ-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. Latham SL, Chaponnier C, Dugina V, et al. FASEB J. 27(2), 672-83, (2013)

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Omi/HtrA2 and XIAP are components of platelet apoptosis signalling. Winkler J, Rand ML, Schmugge M, et al. Thromb. Haemost. 109(3), 532-9, (2013)

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Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface. Mutlu A, Gyulkhandanyan AV, Freedman J, et al. Br. J. Haematol. 163(3), 377-84, (2013)

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Distinct signalling pathways control Toxoplasma egress and host-cell invasion. Lourido S, Tang K, and Sibley LD EMBO J. 31(24), 4524-34, (2012)

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Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. Angin Y, Schwenk RW, Nergiz-Unal R, et al. Am. J. Physiol. Endocrinol. Metab. 307(2), E225-36, (2014)

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AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa. Hurtado de Llera A, Martin-Hidalgo D, Rodriguez-Gil JE, et al. Biochim. Biophys. Acta 1828(9), 2143-51, (2013)

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[Investigation of the changes in uterine myocytes size depending on contractile activity modulators by photon correlation spectroscopy]. Danylovych IuV, Chunikhin OIu, and Danylovych HV Fiziol. Zh. 59(1), 32-9, (2013)

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[Characterisation of enucleated cells apoptosis: human platelets and erythrocytes]. Mindukshev IV, Rukoiatkina NI, Dobrylko IA, et al. Ross. Fiziol. Zh. Im. I. M. Sechenova 99(1), 92-110, (2013)

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[Participation of proteinkinase CK2 in regulation of human erythrocytes plasma membrane redox system activity: relative contribution of ca(2+)-dependent and ca(2+)-independent mechanisms of its activation]. Iakovenko IN, Zhirnov VV, Kozachenko OP, et al. Ukr. Biokhim. Zh. 84(5), 55-61, (2012)

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[Possible pathways of heat resistance induction in plant cells by exogenous nitrogen oxide]. Karpets IuV, Kolupaev IuE, Iastreb TO, et al. Tsitol. Genet. 46(6), 28-35, (2012)

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Enhancement of in vitro interleukin-2 production in normal subjects following a single spinal manipulative treatment. Teodorczyk-Injeyan JA Chiropr. Osteopat. 16, 5, (2008)

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Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase. Guidetti GF, Manganaro D, Consonni A, et al. Biochem. J. 453(1), 115-23, (2013)

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Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function. Condren AB, Kumar A, Mettu P, et al. PLoS ONE 8(1), e53386, (2013)

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Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. McPherson VA Mol. Cell. Biol. 29(2), 389-401, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways. Tateno H, Krapf D, Hino T, et al. Proc. Natl. Acad. Sci. U. S. A. 110(46), 18543-8, (2013)

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The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis. Keinan N, Pahima H, Ben-Hail D, et al. Biochim. Biophys. Acta 1833(7), 1745-54, (2013)

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Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease. Prado GN, Romero JR, and Rivera A FASEB J. 27(11), 4619-29, (2013)

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NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. Yang J, Singh V, Cha B, et al. J. Biol. Chem. 288(23), 16960-74, (2013)

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The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. Xiang B, Zhang G, Stefanini L, et al. J. Biol. Chem. 287(49), 41277-87, (2012)

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Ablation of sarcolipin decreases the energy requirements for Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle. Bombardier E, Smith IC, Vigna C, et al. FEBS Lett. 587(11), 1687-92, (2013)

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Modifying Culture Conditions In Chemical Library Screening Identifies Alternative Inhibitors Of Mycobacteria. Miller, C.H., et al. Antimicrob. Agents Chemother. 53, 5279-83, (2009)

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Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production. Omae T, Nagaoka T, Tanano I, et al. Invest. Ophthalmol. Vis. Sci. 54(3), 2288-95, (2013)

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β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Yang C, Chen ZY, Wong SL, et al. Cardiovasc. Res. 97(3), 520-32, (2013)

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Suppression of chemically induced and spontaneous mouse oocyte activation by AMP-activated protein kinase. Ya R and Downs SM Biol. Reprod. 88(3), 70, (2013)

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Extracting iron and manganese from bacteria with ionophores - a mechanism against competitors characterized by increased potency in environments low in micronutrients. Raatschen N, Wenzel M, Ole Leichert LI, et al. Proteomics 13(8), 1358-70, (2013)

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An insufficient increase of cytosolic free calcium level results postovulatory aging-induced abortive spontaneous egg activation in rat. Premkumar KV and Chaube SK J. Assist. Reprod. Genet. 30(1), 117-23, (2013)

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Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid. Andres D, Keyser BM, Petrali J, et al. BMC Neurosci. 14, 49, (2013)

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Ca(2+)-mediated regulation of VDAC1 expression levels is associated with cell death induction. Weisthal S, Keinan N, Ben-Hail D, et al. Biochim. Biophys. Acta 1843(10), 2270-81, (2014)

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Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant. Gou L, Wu Q, Lin S, et al. Appl. Microbiol. Biotechnol. 97(18), 8183-91, (2013)

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Macrophage recognition of cells with elevated calcium is mediated by carbohydrate chains of CD43. Miki Y, Oguri E, Hirano K, et al. Cell Struct. Funct. 38(1), 43-54, (2013)

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Traction force microscopy in rapidly moving cells reveals separate roles for ROCK and MLCK in the mechanics of retraction. Morin TR, Ghassem-Zadeh SA, and Lee J Exp. Cell Res. 326(2), 280-94, (2014)

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Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: possible clinical use. Maldonado MD, Garcia-Moreno H, and Calvo JR J. Neuroimmunol. 262(1-2), 62-5, (2013)

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Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP. Han NR, Moon PD, Kim HM, et al. Arch. Biochem. Biophys. 542, 14-20, (2014)

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Calcium ameliorates renal cyst growth in metanephric organ culture: a morphological study. Mahajan N, Kaur T, Puri V, et al. J. Environ. Pathol. Toxicol. Oncol. 31(3), 285-93, (2012)

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Bisabololoxide A, one of the constituents in German chamomile extract, attenuates cell death induced by calcium overload. Fukunaga E, Hirao Y, Ogata-Ikeda I, et al. Phytother Res. 28(5), 685-91, (2014)

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Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells. Hosokawa J, Suzuki K, Nakagomi D, et al. Int. Arch. Allergy Immunol. 161 Suppl 2, 37-43, (2013)

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RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity. Lee CJ, Lee MH, Lee JY, et al. Biochem. Biophys. Res. Commun. 440(1), 112-8, (2013)

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Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells. Matsui T, Ito C, Furukawa H, et al. Inflamm. Res. 62(3), 333-41, (2013)

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Immediate and short-, mid- and long-term effects of in vivo ionizing radiation exposure in BALB/c mice: II. activation of phorbol myristate acetate and/or calcium ionophore on lymphocyte proliferation. Hernández-Godoy J, Planelles D, and Balsalobre B In Vivo 27(1), 67-76, (2013)

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Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. Wang HL, Wang LC, and Wei JW Chin. J. Physiol. 56(1), 11-7, (2013)

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