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  • C7597 - Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit

C7597 Sigma

Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chloride Channels, Antibodies to Ion Channels,
species reactivity   rat
application(s)   immunohistochemistry: suitable
  immunoprecipitation: suitable
  western blot (chemiluminescent): 1:200
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   rat ... Clcnkb(79430)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 674-687 of rat longer form CLC-K2L (with additional C-terminal cysteine). The epitope sequence corresponds to the CLC-K2 isotype. It differs by only one residue from rat CLC-K1, or from corresponding human or mouse CLC-Ka or CLC-Kb.

General description

The gene Chloride channel Kb (CLCNKB) is mapped to human chromosome 1p36. It is a kidney specific protein and is present in basolateral membranes of renal tubules.

Physical form

Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and 0.025% sodium azide.


Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit is suitable for the following applications:
• Immunohistochemistry
• Immunoprecipitation
• Western blotting (chemiluminescent) at a dilution of 1:200

Biochem/physiol Actions

Mutations in chloride channel Kb (CLCNKB) gene cause Bartter syndrome (is a salt-losing renal tubulopathy) and is associated with hypertension (EH). Two classes of CLCNKB mutants are distinguished namely, nonconducting mutants associated with low total protein expression and partially conducting mutants with unaltered channel properties and ClC-Kb protein abundance.

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WGK Germany  2
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