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  • C7599 - Anti-Caspase 6 antibody produced in rabbit

C7599 Sigma

Anti-Caspase 6 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Caspases,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:1,000 using Jurkat human T-cell leukemia cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 34 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CASP6(839)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to the human N-terminal of procaspase 6α isoform (amino acids 27-44 with C-terminal added cysteine), conjugated to BSA. This sequence corresponds to the N-terminal of the human enzyme p18 subunit.

General description

Caspase-6 (CASP6) is an enzyme encoded by the CASP6 gene in humans. It is a neuron degeneration-related protease and considered to be a potential drug-design target against neurodegenerative diseases.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide


The antibody reacts specifically with procaspase 6 (Mch2).


Anti-Caspase 6 antibody produced in rabbit is suitable for microarray and western blotting at a dilution of 1:1,000 using Jurkat human T-cell leukemia cell extract.

Biochem/physiol Actions

Caspase-6 is strongly activated in Alzheimer disease brains and Huntington′s disease. It is important in most tissues during early development and is less involved in adult tissues. The low levels of Caspase-6 in fetal and adult brain indicate increased expression in Alzheimer Disease while the high levels of Caspase-6 in the gastrointestinal system indicate specific function of Caspase-6 in this tissues. It is a cysteinyl protease inducing axonal degeneration and is activated early in Alzheimer Disease (AD) brains. Casp6 is associated with the risk of developing AD in aged individuals.

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Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  nwg
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