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C7661 Sigma

Collagen from rat tail

Bornstein and Traub Type I, powder, BioReagent, suitable for cell culture

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Description

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Components

All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type I collagen differs from other collagens by its low lysine hydroxylation and low carbohydrate composition.

Biochem/physiol Actions

Type I collagen is a component of skin, bone, tendon, and other fibrous connective tissues.

Other Notes

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Preparation Note

This product was prepared by a modification of the extraction method of Bornstein, M.B., Lab. Invest., 7, 134 (1958). It is soluble in 0.1 M acetic acid at 1 mg/mL and should be stirred at room temperature for 1-3 hours until dissolved.

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

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Safety & Documentation

Safety Information

WGK Germany 
1

Protocols & Articles

Articles

Collagen Attachment Protocols, Solubility, and Stability

A1) We recommend transferring the collagen solution to a glass bottle with a screw cap and carefully layering chloroform at the bottom. The amount of chloroform to use should be ~10% of the volume of...
George Sitterley
BioFiles 2008, 3.8, 5.
Keywords: Centrifugation, Dialysis, Filtration, Purification, Sterilizations, Type

Collagen Usage Recommendations

Collagen is one of the most abundant proteins in the connective tissues and internal organs of mammals. It provides the tensile strength of the extracellular matrix (ECM). It is classified into a num...
George Sitterley
BioFiles 2008, 3.8, 4.
Keywords: Cell culture, Morphogenesis

The Cancer Stem Cell Hypothesis

Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
Vicki Caligur
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Events, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation

Peer-Reviewed Papers

References

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A comparison of two dental implant systems in partially edentulous patients: 4-month post-loading results from a pragmatic multicentre randomised controlled trial. Esposito M, Blasone R, Favaretto G, et al. Eur. J. Oral Implantol. 6(2), 169-79, (2013)

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1-stage versus 2-stage lateral maxillary sinus lift procedures: 4-month post-loading results of a multicenter randomised controlled trial. Felice P, Pistilli R, Piattelli M, et al. Eur. J. Oral Implantol. 6(2), 153-65, (2013)

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Effect of time between adhesive application and photoactivation on adhesion and collagen exposure. Scheffel DL, Estrêla RP, Pires PM, et al. Am. J. Dent. 27(6), 330-4, (2014)

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Effect of volatile oil from Blumea Balsamifera (L.) DC. leaves on wound healing in mice. Pang Y, Wang D, Hu X, et al. J. Tradit. Chin. Med. 34(6), 716-24, (2014)

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Immediate effect of ultraviolet-a collagen cross-linking therapy on the biomechanics and histology of the human cornea. Del Buey MA, Lanchares E, Cristóbal JÁ, et al. J. Refract. Surg. 31(1), 70-1, (2015)

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Demarcation line evaluation of iontophoresis-assisted transepithelial corneal collagen cross-linking for keratoconus. Bonnel S, Berguiga M, De Rivoyre B, et al. J. Refract. Surg. 31(1), 36-40, (2015)

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Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway. Zhang L, Ji Y, Kang Z, et al. Toxicol. Appl. Pharmacol. 283(1), 50-6, (2015)

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The BREASTrial: stage I. Outcomes from the time of tissue expander and acellular dermal matrix placement to definitive reconstruction. Mendenhall SD, Anderson LA, Ying J, et al. Plast. Reconstr. Surg. 135(1), 29e-42e, (2015)

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De novo design based pharmacophore query generation and virtual screening for the discovery of Hsp-47 inhibitors. Katarkar A, Haldar PK, and Chaudhuri K Biochem. Biophys. Res. Commun. 456(3), 707-13, (2015)

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Flapless alveolar ridge preservation utilizing the "socket-plug" technique: clinical technique and review of the literature. Kotsakis G, Chrepa V, Marcou N, et al. J. Oral Implantol. 40(6), 690-8, (2014)

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Role of rhBMP-2 and rhBMP-7 in the metabolism and differentiation of osteoblast-like cells cultured on chemically modified titanium surfaces. Cirano FR, Togashi AY, Marques MM, et al. J. Oral Implantol. 40(6), 655-9, (2014)

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Extragenital lichen sclerosus: clinical, dermoscopic, confocal microscopy and histologic correlations. Lacarrubba F, Pellacani G, Verzì AE, et al. J. Am. Acad. Dermatol. 72(1 Suppl), S50-2, (2015)

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Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Shimizu J, Asami N, Kataoka A, et al. Biochem. Biophys. Res. Commun. 456(2), 626-30, (2015)

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Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Martino L, Pennell S, Kelly G, et al. Nucleic Acids Res. 43(1), 645-60, (2015)

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Reply: To PMID 24878307. Alessio G, L'abbate M, Furino C, et al. Am. J. Ophthalmol. 159(1), 204-5, (2015)

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Confocal microscopy analysis of corneal changes after photorefractive keratectomy plus cross-linking for keratoconus: 4-year follow-up. Kymionis GD and Diakonis VF Am. J. Ophthalmol. 159(1), 203-4, (2015)

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Relationship between elasticity and collagen fiber content in breast disease: a preliminary report. Wang ZL, Sun L, Li Y, et al. Ultrasonics 57, 44-9, (2015)

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Re: Said et al.: Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting (Ophthalmology 2014;121:1377-82). Mittal R and Garg P Ophthalmology 121(12), e67-8, (2014)

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Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging. Sehgel NL, Sun Z, Hong Z, et al. Hypertension 65(2), 370-7, (2015)

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Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway. Yoshimoto T, Takino T, Li Z, et al. Biochem. Biophys. Res. Commun. 455(3-4), 251-5, (2014)

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Quantification of the effect of Lipo-PGE1 on angiogenesis. Eo S, Kwon C, Lee H, et al. J. Plast. Reconstr. Aesthet. Surg. 68(1), 104-12, (2015)

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Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model. Chaichalotornkul S, Nararatwanchai T, Narkpinit S, et al. Biochem. Biophys. Res. Commun. 456(1), 92-7, (2015)

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Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen. Hare AK and Harris EN Biochem. Biophys. Res. Commun. 456(1), 257-61, (2015)

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Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis. Tabibian D, Richoz O, Riat A, et al. J. Refract. Surg. 30(12), 855-7, (2014)

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Accelerated corneal cross-linking in pediatric patients with keratoconus: 24-month outcomes. Ozgurhan EB, Kara N, Cankaya KI, et al. J. Refract. Surg. 30(12), 843-9, (2014)

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Evaluation of corneal changes after conventional versus accelerated corneal cross-linking: a randomized controlled trial. Hashemian H, Jabbarvand M, Khodaparast M, et al. J. Refract. Surg. 30(12), 837-42, (2014)

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DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. Zhang Q, Dove CG, Hor JL, et al. J. Exp. Med. 211(13), 2549-66, (2014)

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Micro-RNA 21Targets dual specific phosphatase 8 to promote collagen synthesis in high glucose-treated primary cardiac fibroblasts. Liu S, Li W, Xu M, et al. Can. J. Cardiol. 30(12), 1689-99, (2014)

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Microfocused ultrasound with visualization and fillers for increased neocollagenesis: clinical and histological evaluation. Casabona G and Michalany N Dermatol. Surg. 40 Suppl 12, S194-8, (2014)

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Fillers and neocollagenesis. Carruthers JD, Carruthers JA, and Humphrey S Dermatol. Surg. 40 Suppl 12, S134-6, (2014)

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Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling. Li J, Jubair S, and Janicki JS Hypertension 65(2), 328-34, (2015)

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Distribution volumes of macromolecules in human ovarian and endometrial cancers--effects of extracellular matrix structure. Haslene-Hox H, Oveland E, Woie K, et al. Am. J. Physiol. Heart Circ. Physiol. 308(1), H18-28, (2015)

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Transepithelial iontophoresis corneal collagen cross-linking for progressive keratoconus: initial clinical outcomes. Vinciguerra P, Randleman JB, Romano V, et al. J. Refract. Surg. 30(11), 746-53, (2014)

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Age-related changes in rat dermal extracellular matrix composition affect the distribution of plasma proteins as a function of size and charge. Sagstad SJ, Oveland E, Karlsen TV, et al. Am. J. Physiol. Heart Circ. Physiol. 308(1), H29-38, (2015)

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The needle in the ECM haystack. Kadler KE Nat. Rev. Mol. Cell Biol. 15(12), 769, (2014)

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The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Astarita JL, Cremasco V, Fu J, et al. Nat. Immunol. 16(1), 75-84, (2015)

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Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions. Wu D, Jiao M, Zu S, et al. J. Biol. Chem. 289(49), 34033-48, (2014)

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Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Raghu H, Cruz C, Rewerts CL, et al. Blood 125(3), 427-37, (2015)

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Effect of supraspinatus tendon injury on supraspinatus and infraspinatus muscle passive tension and associated biochemistry. Silldorff MD, Choo AD, Choi AJ, et al. J. Bone Joint Surg. Am. 96(20), e175, (2014)

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Optimization of radiation therapy techniques for prostate cancer with prostate-rectum spacers: a systematic review. Mok G, Benz E, Vallee JP, et al. Int. J. Radiat. Oncol. Biol. Phys. 90(2), 278-88, (2014)

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Additive effect of repeated corneal collagen cross-linking in keratoconus. Hafezi F, Tabibian D, and Richoz O J. Refract. Surg. 30(10), 716-8, (2014)

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Outcome of abdominal wall hernia repair with biologic mesh: Permacol™ versus Strattice™. Cheng AW, Abbas MA, and Tejirian T Am. Surg. 80(10), 999-1002, (2014)

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Discussion. Surgery 156(4), 908-9, (2014)

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A prospective, randomized, multicenter trial of Surgisis Gold, a biologic prosthetic, as a sublay reinforcement of the fascial closure after open bariatric surgery. Sarr MG, Hutcher NE, Snyder S, et al. Surgery 156(4), 902-8, (2014)

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Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. Rosa AC, Pini A, Lucarini L, et al. J. Pharmacol. Exp. Ther. 351(2), 308-16, (2014)

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Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis. Le TT, Karmouty-Quintana H, Melicoff E, et al. J. Immunol. 193(7), 3755-68, (2014)

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The use of a dermal substitute for simultaneous flap delay and donor site coverage in two cases. Behar BJ, Abdollahi H, Ranganath B, et al. J. Wound Care 23(7), S15-9, (2014)

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Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells. Ren H, Jia L, Zhao T, et al. Cancer Lett. 354(1), 172-80, (2014)

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Bio-Emulation: biomimetically emulating nature utilizing a histoanatomic approach; visual synthesis. Bazos P and Magne P Int. J. Esthet. Dent. 9(3), 330-52, (2014)

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Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of progressive myopia in a rabbit model. Dotan A, Kremer I, Livnat T, et al. Exp. Eye Res. 127, 190-5, (2014)

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Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization. Kim YH, Yoo KC, Cui YH, et al. Cancer Lett. 354(1), 132-41, (2014)

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Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Bi Y, Mukhopadhyay D, Drinane M, et al. Am. J. Physiol. Cell Physiol. 307(7), C622-33, (2014)

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Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model. Reuther KE, Thomas SJ, Tucker JJ, et al. J. Orthop. Res. 32(11), 1436-43, (2014)

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Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis. Hu M, Che P, Han X, et al. J. Pharmacol. Exp. Ther. 351(1), 87-95, (2014)

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Gene expression analysis in patients with traumatic anterior shoulder instability suggests deregulation of collagen genes. Belangero PS, Leal MF, Figueiredo EA, et al. J. Orthop. Res. 32(10), 1311-6, (2014)

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A novel approach to reconstruct a large full thickness abdominal wall defect: successful treatment with MatriDerm® and Split. Tong E, Martin F, and Shelley O J. Wound Care 23(7), 355-7, (2014)

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Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol. Kymionis GD, Tsoulnaras KI, Grentzelos MA, et al. Am. J. Ophthalmol. 158(4), 671-675.e1, (2014)

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Invited commentary. Ye X Ann. Thorac. Surg. 98(1), 71, (2014)

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PACK-CXL: defining CXL for infectious keratitis. Hafezi F and Randleman JB J. Refract. Surg. 30(7), 438-9, (2014)

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An unusual finding in a man with GERD. Harp GM, DeRoche T, and Lacey BW Gastroenterology 147(2), e7-9, (2014)

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Effects of celecoxib on proliferation and tenocytic differentiation of tendon-derived stem cells. Zhang K, Zhang S, Li Q, et al. Biochem. Biophys. Res. Commun. 450(1), 762-6, (2014)

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Angio-Seal hopes for antegrade puncture require better evidence. Ricco JB and Schneider F Eur. J. Vasc. Endovasc. Surg. 48(2), 226-7, (2014)

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Measuring localization and diffusion coefficients of basolateral proteins in lateral versus basal membranes using functionalized substrates and kICS analysis. Marlar S, Arnspang EC, Pedersen GA, et al. Biochim. Biophys. Acta 1838(10), 2404-11, (2014)

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Hajek revisited: a histological examination of the quadrangular membrane. Young N, Abdelmessih MW, and Sasaki C Ann. Otol. Rhinol. Laryngol. 123(11), 765-8, (2014)

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Structural characterization and interaction of periostin and bone morphogenetic protein for regulation of collagen cross-linking. Hwang EY, Jeong MS, Park EK, et al. Biochem. Biophys. Res. Commun. 449(4), 425-31, (2014)

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Gelatin hydrogel as a carrier of recombinant human fibroblast growth factor-2 during rat mandibular distraction. Kimura A, Kabasawa Y, Tabata Y, et al. J. Oral Maxillofac. Surg. 72(10), 2015-31, (2014)

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Modifying the vessel walls in porcine kidneys during machine perfusion. Sedigh A, Larsson R, Brännström J, et al. J. Surg. Res. 191(2), 455-62, (2014)

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Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: an experimental study. Tsitsilonis S, Panayiotis CE, Athanasios MS, et al. Foot Ankle Surg. 20(2), 94-9, (2014)

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Novel thrombolytic protease from edible and medicinal plant Aster yomena (Kitam.) Honda with anticoagulant activity: purification and partial characterization. Choi JH, Kim DW, Park SE, et al. J. Biosci. Bioeng. 118(4), 372-7, (2014)

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Micropatterned culture of HepG2 spheroids using microwell chip with honeycomb-patterned polymer film. Yamazaki H, Gotou S, Ito K, et al. J. Biosci. Bioeng. 118(4), 455-60, (2014)

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The intracellular juxtamembrane domain of discoidin domain receptor 2 (DDR2) is essential for receptor activation and DDR2-mediated cancer progression. Kim D, Ko P, You E, et al. Int. J. Cancer 135(11), 2547-57, (2014)

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From the cutting edge: patch heals heart. Harv. Heart Lett. 24(3), 8, (2013)

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Self-organizing stem cells. de Souza N Nature Methods 11(1), 31, (2014)

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Studies on the effect of antidiabetic drugs on collagen in rats. Lekshmi UM and Reddy PN Pak. J. Biol. Sci. 16(22), 1545-50, (2013)

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Implant placement in the aesthetic zone following an autogenous bone graft from an intraoral site: a case study. Sullivan JP Prim. Dent. J. 2(4), 49-55, (2013)

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TGF-beta1-Induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells. Das D, Holmes A, Murphy GA, et al. J. Heart Valve Dis. 22(5), 621-30, (2013)

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Clinical and radiographic evaluation of single-tooth dental implants placed in grafted extraction sites: a one-year report. Kutkut A, Andreana S, and Monaco E J. Int. Acad. Periodontol. 15(4), 113-24, (2013)

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Peripheral nerve repair and reconstruction. Griffin JW, Hogan MV, Chhabra AB, et al. J. Bone Joint Surg. Am. 95(23), 2144-51, (2013)

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Invited commentary. Ge L and Tseng EE Ann. Thorac. Surg. 96(6), 2154, (2013)

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[Intravital optical imaging of bone and cartilage tissues]. Imamura T, Hikita A, Oshima Y, et al. Clin. Calcium 23(12), 1767-73, (2013)

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[Development of meniscus biomaterial]. Nakata K, Mae T, Yonetani Y, et al. Clin. Calcium 23(12), 1731-9, (2013)

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Electrospun collagen mimicking the reconstituted extracellular matrix improves osteoblastic differentiation onto titanium surfaces. Iafiscol M, Quirici N, Foltran I, et al. J. Nanosci. Nanotechnol. 13(7), 4720-6, (2013)

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Fabrication of seamless electrospun collagen/PLGA conduits whose walls comprise highly longitudinal aligned nanofibers for nerve regeneration. Ouyang Y, Huang C, Zhu Y, et al. J. Biomed. Nanotechnol. 9(6), 931-43, (2013)

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[Autochthonous probiotics in prevention of infectious and inflammatory diseases of a human in the altered habitats]. Il'in VK, Suvorov AN, Kiriukhina NV, et al. Vestn. Ross. Akad. Med. Nauk (2), 56-62, (2013)

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Reply. Nagaraj H, Shetty R, Kumar RS, et al. J. Refract. Surg. 29(6), 377, (2013)

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[Novel autoantibodies in myasthenia gravis]. Nagaishi A, Sakai W, and Motomura M Nihon Rinsho. 71(5), 876-80, (2013)

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Effect of Allium sativum and fish collagen on the proteolytic and angiotensin-I converting enzyme-inhibitory activities in cheese and yogurt. Shori AB, Baba AS, and Keow JN Pak. J. Biol. Sci. 15(24), 1160-7, (2012)

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[External changes of the face soft tissues as a marker of degenerative changes in collagen]. Vereshchaka VV Fiziol. Zh. 59(1), 97-109, (2013)

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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Lämmermann T, Afonso PV, Angermann BR, et al. Nature 498(7454), 371-5, (2013)

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[The role of electrothermoadhesion in creation of artificial vocal cord, and the voice quality improvement following chordectomy for laryngeal cancer]. Abyzov RA, Onyshchenko IuI, and Romas' OIu Klin. Khir. (2), 77, (2013)

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Protective effects of deswelling on stromal collagen denaturation after a corneal femtosecond laser cut. Rossi M, Mistò R, Gatto C, et al. Invest. Ophthalmol. Vis. Sci. 54(6), 4148-57, (2013)

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Tensile characterization of porcine temporomandibular joint disc attachments. Murphy MK, Arzi B, Hu JC, et al. J. Dent. Res. 92(8), 753-8, (2013)

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Sources of structural autofluorescence in the human trabecular meshwork. Huang AS, Gonzalez JM, Le PV, et al. Invest. Ophthalmol. Vis. Sci. 54(7), 4813-20, (2013)

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Very high fluence collagen cross-linking as a refractive enhancement of a regressed previous astigmatic keratotomy. Kanellopoulos AJ J. Refract. Surg. 29(7), 504-5, (2013)

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Corneal collagen cross-linking in the stabilization of PRK, LASIK, thermal keratoplasty, and orthokeratology. Nguyen MK and Chuck RS Curr. Opin. Ophthalmol. 24(4), 291-5, (2013)

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Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. Lu D and Insel PA J. Biol. Chem. 288(26), 19040-9, (2013)

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High fluence iontophoretic corneal collagen cross-linking: in vivo OCT imaging of riboflavin penetration. Vinciguerra P, Rechichi M, Rosetta P, et al. J. Refract. Surg. 29(6), 376-7, (2013)

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Topography-guided laser refractive surgery. Holland S, Lin DT, and Tan JC Curr. Opin. Ophthalmol. 24(4), 302-9, (2013)

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Impact of fluorescein on the antimicrobial efficacy of photoactivated riboflavin in corneal collagen cross-linking. Richoz O, Gatzioufas Z, Francois P, et al. J. Refract. Surg. 29(12), 842-5, (2013)

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Treatment with local hemostatic agents and primary closure after tooth extraction in warfarin treated patients. Svensson R, Hallmer F, Englesson CS, et al. Swed. Dent. J. 37(2), 71-7, (2013)

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The in vivo effect of esculetin ointment and esculetin-mixed Zyderm for Zyderm. Yamaoka H, Nishizawa S, Matsui M, et al. Plast. Reconstr. Surg. 134(1), 50e-58e, (2014)

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The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis. Hou Y, Lin H, Zhu L, et al. J. Immunol. 193(1), 130-8, (2014)

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Surgical treatment of single gingival recessions: clinical guidelines. Pini-Prato G, Nieri M, Pagliaro U, et al. Eur. J. Oral Implantol. 7(1), 9-43, (2014)

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Bone tissue engineering by way of allograft revitalization: mechanistic and mechanical investigations using a porcine model. Runyan CM, Ali ST, Chen W, et al. J. Oral Maxillofac. Surg. 72(5), 1000.e1-11, (2014)

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Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy. Li W, Mata KM, Mazzuca MQ, et al. Biochem. Pharmacol. 89(3), 370-85, (2014)

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Evaluation of prostate-specific membrane antigen as an imaging reporter. Castanares MA, Mukherjee A, Chowdhury WH, et al. J. Nucl. Med. 55(5), 805-11, (2014)

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CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. Tanaka T, Wakabayashi T, Oizumi H, et al. J. Neurosci. 34(4), 1370-9, (2014)

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Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling. Bastiaans J, van Meurs JC, van Holten-Neelen C, et al. Invest. Ophthalmol. Vis. Sci. 54(13), 8306-14, (2013)

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Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Swift J, Ivanovska IL, Buxboim A, et al. Science 341(6149), 1240104, (2013)

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Effectiveness of topical maxacalcitol for acquired perforating disorder. Yoshiya H, Okuyama R, and Uhara H J. Am. Acad. Dermatol. 68(6), e181-2, (2013)

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Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity. Gawri R, Ouellet J, Önnerfjord P, et al. J. Orthop. Res. 32(9), 1189-97, (2014)

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Skeletal muscle fibrosis and stiffness increase after rotator cuff tendon injury and neuromuscular compromise in a rat model. Sato EJ, Killian ML, Choi AJ, et al. J. Orthop. Res. 32(9), 1111-6, (2014)

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Developments in preclinical cancer imaging: innovating the discovery of therapeutics. Conway JR, Carragher NO, and Timpson P Nat. Rev. Cancer 14(5), 314-28, (2014)

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A mechanical model of the cornea considering the crimping morphology of collagen fibrils. Liu X, Wang L, Ji J, et al. Invest. Ophthalmol. Vis. Sci. 55(4), 2739-46, (2014)

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Rotator cuff tendon ultrastructure assessment with reduced-orientation dipolar anisotropy fiber imaging. Chang EY, Szeverenyi NM, Statum S, et al. AJR Am. J. Roentgenol. 202(4), W376-8, (2014)

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Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma. Sham JG, Kievit FM, Grierson JR, et al. J. Nucl. Med. 55(5), 799-804, (2014)

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Earliest evidence for commensal processes of cat domestication. Hu Y, Hu S, Wang W, et al. Proc. Natl. Acad. Sci. U. S. A. 111(1), 116-20, (2014)

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IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Hams E, Armstrong ME, Barlow JL, et al. Proc. Natl. Acad. Sci. U. S. A. 111(1), 367-72, (2014)

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Dietary trans-10,cis-12 CLA reduces murine collagen-induced arthritis in a dose-dependent manner. Huebner SM, Olson JM, Campbell JP, et al. J. Nutr. 144(2), 177-84, (2014)

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Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. Harpaz N, Ordan E, Ocorr K, et al. PLoS Genet. 9(6), e1003597, (2013)

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Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts. Li H, Ezra DG, Burton MJ, et al. Invest. Ophthalmol. Vis. Sci. 54(7), 4675-82, (2013)

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Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Hammer A, Richoz O, Arba Mosquera S, et al. Invest. Ophthalmol. Vis. Sci. 55(5), 2881-4, (2014)

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Different collagen types show distinct rates of increase from early to late stages of hepatitis C-related liver fibrosis. Chen W, Rock JB, Yearsley MM, et al. Hum. Pathol. 45(1), 160-5, (2014)

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Big bubble DALK after CXL in keratoconic patients. Iovieno A, Moramarco A, Coassin M, et al. J. Refract. Surg. 29(12), 801, (2013)

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Visian toric ICL implantation for residual refractive errors after ICRS implantation and corneal collagen cross-linking in keratoconus. Jarade E, Dirani A, Fadlallah A, et al. J. Refract. Surg. 29(7), 444, (2013)

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Site specific properties of carious dentin matrices biomodified with collagen cross-linkers. Bedran-Russo AK, Karol S, Pashley DH, et al. Am. J. Dent. 26(5), 244-8, (2013)

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Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques. van Montfoort ML, Kuijpers MJ, Knaup VL, et al. Arterioscler. Thromb. Vasc. Biol. 34(8), 1668-73, (2014)

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MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase. Zhang Y, Ghazwani M, Li J, et al. Biochem. Biophys. Res. Commun. 446(4), 940-4, (2014)

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Collagen cross-linking and corneal infections. Tayapad JB, Viguilla AQ, and Reyes JM Curr. Opin. Ophthalmol. 24(4), 288-90, (2013)

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Wound healing and the role of fibroblasts. Bainbridge P J. Wound Care 22(8), 407-8, 410-12, (2013)

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Preparation and characterization of gelatin from collagen biomass obtained through a pH-shifting process of mechanically separated turkey meat. Du L, Keplová L, Khiari Z, et al. Poult. Sci. 93(4), 989-1000, (2014)

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Evaluation of canine bone marrow-derived mesenchymal stem cells after long-term cryopreservation. Zhu X, Yuan F, Li H, et al. Zoolog. Sci. 30(12), 1032-7, (2013)

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Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. Sriram S, Robinson P, Pi L, et al. Invest. Ophthalmol. Vis. Sci. 54(13), 8214-23, (2013)

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Contribution of oxidative stress to the degeneration of rotator cuff entheses. Morikawa D, Itoigawa Y, Nojiri H, et al. J. Shoulder Elbow Surg. 23(5), 628-35, (2014)

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Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation. Dixon JE, Shah DA, Rogers C, et al. Proc. Natl. Acad. Sci. U. S. A. 111(15), 5580-5, (2014)

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Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. Kymionis GD, Grentzelos MA, Plaka AD, et al. J. Refract. Surg. 30(4), 272-6, (2014)

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Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study. Arboleda A, Kowalczuk L, Savoldelli M, et al. Invest. Ophthalmol. Vis. Sci. 55(4), 2731-8, (2014)

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A detailed examination of platelet function inhibition by nitric oxide in platelet-rich plasma and whole blood. Zimmermann R, Krueger J, Filipović MR, et al. Clin. Lab. 59(5-6), 629-38, (2013)

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Electrospun collagen/poly(L-lactic acid-co-epsilon-caprolactone) hybrid nanofibrous membranes combining with sandwich construction model for cartilage tissue engineering. He X, Fu W, Feng B, et al. J. Nanosci. Nanotechnol. 13(6), 3818-25, (2013)

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A preclinical rodent model of acute radiation-induced lung injury after ablative focal irradiation reflecting clinical stereotactic body radiotherapy. Hong ZY, Lee HJ, Choi WH, et al. Radiat. Res. 182(1), 83-91, (2014)

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Protection of corneal epithelial stem cells prevents ultraviolet A damage during corneal collagen cross-linking treatment for keratoconus. Moore JE, Atkinson SD, Azar DT, et al. Br. J. Ophthalmol. 98(2), 270-4, (2014)

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1-stage versus 2-stage lateral sinus lift procedures: 1-year post-loading results of a multicentre randomised controlled trial. Felice P, Pistilli R, Piattelli M, et al. Eur. J. Oral Implantol. 7(1), 65-75, (2014)

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Late onset of a persistent, deep stromal scarring after PRK and corneal cross-linking in a patient with forme fruste keratoconus. Güell JL, Verdaguer P, Elies D, et al. J. Refract. Surg. 30(4), 286-8, (2014)

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Aegyptin inhibits collagen-induced coagulation activation in vitro and thromboembolism in vivo. Mizurini DM, Francischetti IM, and Monteiro RQ Biochem. Biophys. Res. Commun. 436(2), 235-9, (2013)

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Opposing changes in thoracic and abdominal aortic biomechanical properties in rodent models of vascular calcification and hypertension. Ameer OZ, Salman IM, Avolio AP, et al. Am. J. Physiol. Heart Circ. Physiol. 307(2), H143-51, (2014)

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Rosuvastatin inhibits TGF-beta1 expression and alleviates myocardial fibrosis in diabetic rats. Ma YX, Li WH, and Xie Q Pharmazie 68(5), 355-8, (2013)

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Response surface methodology and Taguchi approach to assess the combined effect of formulation factors on minocycline delivery from collagen sponges. Ghica MV, Albu MG, Popa L, et al. Pharmazie 68(5), 340-8, (2013)

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Collagen/Wollastonite nanowire hybrid scaffolds promoting osteogenic differentiation and angiogenic factor expression of mesenchymal stem cells. Zhang Q, Nakamoto T, Chen S, et al. J. Nanosci. Nanotechnol. 14(4), 3221-7, (2014)

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Guided bone regeneration using chitosan-collagen membranes in dog dehiscence-type defect model. Li X, Wang X, Zhao T, et al. J. Oral Maxillofac. Surg. 72(2), 304.e1-14, (2014)

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Abnormal lipid metabolism in collagen-induced arthritis rat model: in vitro, high resolution NMR spectroscopy based analysis. Srivastava NK, Sharma S, Purusottam RN, et al. Indian J. Exp. Biol. 52(7), 673-82, (2014)

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MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells. Lund DK, Mouly V, and Cornelison DD Am. J. Physiol. Cell Physiol. 307(2), C140-9, (2014)

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Corneal cross-linking for treatment of progressive keratoconus in various age groups. Soeters N, van der Valk R, and Tahzib NG J. Refract. Surg. 30(7), 454-60, (2014)

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Corneal collagen cross-linking for Terrien marginal degeneration. Hafezi F, Gatzioufas Z, Seiler TG, et al. J. Refract. Surg. 30(7), 498-500, (2014)

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Biomechanical properties of the thoracic aneurysmal wall: differences between bicuspid aortic valve and tricuspid aortic valve patients. Forsell C, Björck HM, Eriksson P, et al. Ann. Thorac. Surg. 98(1), 65-71, (2014)

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Percutaneous vascular closure using an anchored collagen plug provides effective haemostasis following both antegrade and retrograde femoral arterial punctures. Chaudhuri A, York A, and Dey R Eur. J. Vasc. Endovasc. Surg. 48(2), 220-5, (2014)

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Lack of identifiable biologic behavior in a series of porcine mesh explants. De Silva GS, Krpata DM, Gao Y, et al. Surgery 156(1), 183-9, (2014)

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In vitro model to study the biomaterial-dependent reaction of macrophages in an inflammatory environment. Grotenhuis N, Vd Toom HF, Kops N, et al. Br. J. Surg. 101(8), 983-92, (2014)

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Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension. Nave AH, Mižíková I, Niess G, et al. Arterioscler. Thromb. Vasc. Biol. 34(7), 1446-58, (2014)

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Successful closure of gastrocutaneous fistulas using the Surgisis(®) anal fistula plug. Darrien JH and Kasem H Ann. R. Coll. Surg. Engl. 96(4), 271-4, (2014)

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Nasopalatine duct cyst, a delayed complication to successful dental implant placement: diagnosis and surgical management. McCrea SJ J. Oral Implantol. 40(2), 189-95, (2014)

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Protein-polymer functionalized aqueous ferrofluids showing high T2 relaxivity. Bhattacharya S, Sheikh L, Tiwari V, et al. J. Biomed. Nanotechnol. 10(5), 811-9, (2014)

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Favorable effect of myofibroblasts on collagen synthesis and osteocalcin production in the periodontal ligament. Xu H, Han X, Meng Y, et al. Am. J. Orthod. Dentofacial Orthop. 145(4), 469-79, (2014)

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The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle. Tajrishi MM, Sato S, Shin J, et al. Biochem. Biophys. Res. Commun. 446(4), 1219-24, (2014)

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Structural modifications and tissue response after standard epi-off and iontophoretic corneal crosslinking with different irradiation procedures. Mastropasqua L, Lanzini M, Curcio C, et al. Invest. Ophthalmol. Vis. Sci. 55(4), 2526-33, (2014)

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Degradation of oxidized and glycoxidized collagen: role of collagen cross-linking. Nowotny K and Grune T Arch. Biochem. Biophys. 542, 56-64, (2014)

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Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction. Koike K, Ueda S, Yamagishi S, et al. Clin. Immunol. 150(1), 78-87, (2014)

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[Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders]. Sabaliauskiene Z, Gribauskas P, Gaigalaite V, et al. Ter. Arkh. 85(3), 75-9, (2013)

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