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C7696 Sigma

Cyclophilin A from calf thymus

powder

Synonym: CyP

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Description

Packaging

0.1 mg in poly bottle

Quality

Highly purified, lyophilized powder, balance primarily NaCl, HEPES, DTT, PMSF, sodium azide and stabilizer.

Biochem/physiol Actions

Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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