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C7698 Sigma

Cycloheximide

from microbial, ≥94% (TLC)

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Bioactive Small Molecule Alphabetical Index,
biological source   from microbial
InChI Key   YPHMISFOHDHNIV-FSZOTQKASA-N
assay   ≥94% (TLC)
form   powder
mp   110 °C
solubility   ethanol: soluble, clear to hazy
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
  yeast
storage temp.   2-8°C
Gene Information   human ... FKBP1A(2280), PIN1(5300)

Description

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Packaging

1, 5 g in poly bottle

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
MA4375000
Protocols & Articles

Protocols

Antibiotics - Plant Tissue Culture Protocol

In general, antibiotics require storage in a refrigerator or freezer. Aminoglycosides (e.g. kanamycin) are hygroscopic and should be stored in a desiccator. Storage of many powdered antibiotics at -2...
Keywords: Adsorption, Antibiotics, Antifungals, Condensations, Molecular biology

Peer-Reviewed Papers
15

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