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C7698 Sigma

Cycloheximide

from microbial, ≥94% (TLC)

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Bioactive Small Molecule Alphabetical Index,
biological source   from microbial
InChI Key   YPHMISFOHDHNIV-FSZOTQKASA-N
assay   ≥94% (TLC)
form   powder
solubility   ethanol: soluble, clear
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
  yeast
storage temp.   2-8°C
Gene Information   human ... FKBP1A(2280), PIN1(5300)

Description

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Packaging

1, 5 g in poly bottle

Application

• In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
• It has been used to inhibit translation in mammalian cells.
• It has been used to suppress fungal growth.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Protocols & Applications

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
MA4375000
Protocols & Articles

Protocols

Antibiotics - Plant Tissue Culture Protocol

In general, antibiotics require storage in a refrigerator or freezer. Aminoglycosides (e.g. kanamycin) are hygroscopic and should be stored in a desiccator. Storage of many powdered antibiotics at -2...
Keywords: Adsorption, Antibiotics, Antifungals, Condensations, Molecular biology

Peer-Reviewed Papers
15

References

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