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C7785 Sigma

Monoclonal Anti-Cytokeratin 18 antibody produced in mouse

clone CK5, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
species reactivity   human
application(s)   indirect immunofluorescence: 1:50 using frozen human tissue sections
  microarray: suitable
clone   CK5, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KRT18(3875)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

keratin from a human bladder carcinoma cell line.

General description

Keratin 18 (K18) is a type I cytokeratin. Cytokeratin 18 (CYK18) is a cytoskeletal protein associated with apoptosis. It is studied that cytokeratin 18 levels in the mild pancreatitis group were significantly higher than in the severe pancreatitis group. It acts as a marker of apoptosis and might be a serological predictive marker for acute pancreatitis for disease activity. CK-18 is considered as a promising plasma biomarker to identify patients with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.

Specificity

Binds to an epitope present on human cytokeratin polypeptide 18 of the acidic cytokeratin subfamily. The antibody reacts with a variety of simple epithelia (e.g., intestine, liver), but does not stain stratified squamous epithelia (e.g., esophagus, epidermis) or non-epithelial cells.

Application

Monoclonal Anti-Cytokeratin CK5 antibody produced in mouse is suitable for microarray and indirect immunofluorescence at a dilution of 1:50 using frozen human tissue sections.

Price and Availability


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