|Related Categories||Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Ion Channel Modulating Peptides,|
human ... KCNA3(3738)|
mouse ... KCNA3(16491)
rat ... KCNA3(29731)
Peptide found in the venom of the scorpion Leiurus quinquestriatus.
High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
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from bee venom, ≥95% (HPLC)
synthetic, ≥97% (HPLC)
recombinant, expressed in E. coli, lyophilized powder
≥98% (HPLC), recombinant, expressed in E. coli
Certificate of Analysis
Certificate of Origin
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. Mackenzie A, Dunning L, Ferrell WR, et al. Life Sci. 92(23), 1131-7, (2013)
Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. Feng J, Hu Y, Yi H, et al. J. Biol. Chem. 288(18), 12544-53, (2013)
Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves. Nakamura K, Shimizu T, Tanaka K, et al. Eur. J. Pharmacol. 694(1-3), 98-103, (2012)
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. Baranowska-Kuczko M, MacLean MR, Kozłowska H, et al. Pharmacol. Res. 66(3), 251-9, (2012)
Involvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension test. Moretti M, Budni J, Ribeiro CM, et al. Eur. J. Pharmacol. 687(1-3), 21-7, (2012)
Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison. Nikouee A, Khabiri M, Grissmer S, et al. J. Phys. Chem. B 116(17), 5132-40, (2012)
Inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons in the ventrolateral medulla of neonatal rat are different in intrinsic electrophysiological properties. Chen Y, Hou L, Zhou X, et al. Respir. Physiol. Neurobiol. 180(2-3), 323-30, (2012)
The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice. Chen X, Li Y, Hollenberg M, et al. J. Cardiovasc. Pharmacol. 59(5), 413-25, (2012)
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. Wang K, Terrenoire C, Sampson KJ, et al. J. Physiol. 589(Pt 24), 6093-104, (2011)
Endothelial-derived hyperpolarization factor (EDHF) contributes to PlGF-induced dilation of mesenteric resistance arteries from pregnant rats. Mandalà M, Gokina N, Barron C, et al. J. Vasc. Res. 49(1), 43-9, (2012)
The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Pulkkinen V, Manson ML, Säfholm J, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 303(11), L956-66, (2012)
Relaxant effect of a water soluble carbon monoxide-releasing molecule (CORM-3) on spontaneously hypertensive rat aortas. Failli P, Vannacci A, Di Cesare Mannelli L, et al. Cardiovasc. Drugs Ther. 26(4), 285-92, (2012)
Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice. Budni J, Freitas AE, Binfaré RW, et al. Pharmacol. Biochem. Behav. 101(1), 148-54, (2012)
Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation. Behringer EJ, Shaw RL, Westcott EB, et al. Arterioscler. Thromb. Vasc. Biol. 33(8), 1892-901, (2013)
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