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  • C7977 - Anti-CIDE-A, C-Terminal antibody produced in rabbit

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C7977 Sigma

Anti-CIDE-A, C-Terminal antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Cell Death-Inducing DFF-like Effector A

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to DNA Fragmentation,
species reactivity   human, mouse
application(s)   ELISA: suitable
  immunofluorescence: suitable
  immunohistochemistry: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 25 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Cidea(12683)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 200-214 of the C-terminal of mouse CIDE-A.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Application

Anti-CIDE-A, C-Terminal antibody was used in western blot at 0.5 μg/ml, immunohistochemistry starting at 2.5 μg/ml and for immunofluorescence start at 20 μg/mL.

Biochem/physiol Actions

Apoptosis or Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family proteases. These signals are generated by DNase in chromosomal DNA degradation. CIDE-A and CIDE-B induce DNA fragmentation and activate apoptosis in mammalian cells. The C-terminal region of CIDE-A is necessary and sufficient for killing. DFF45/ICAD is an inhibitor of caspase activated Dnase, DFF40/CAD and has also been shown to inhibit the apoptotic activities of CIDE-A and CIDE-B. The region of CIDE-A with homology to DFF45 located in the N-terminus was required for DFF45 to inhibit CIDE-A induced apoptosis. CIDE-A is expressed in a number of tissues including kidney and heart.

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