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C8032 Sigma

α-Casein Dephosphorylated from bovine milk

lyophilized powder

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Properties

Related Categories Biochemicals and Reagents, Casein and Other Milk Proteins, Proteins and Derivatives More...
form   lyophilized powder
storage temp.   −20°C

Description

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

Preparation Note

Enzymatically prepared from C6780.

Quality

At least 80% dephosphorylated.

Application

α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.

Biochem/physiol Actions

Clusters of phosphoserine in casein chelate iron and reduce its bioavailability. Partial enzymatic digestion of casein unmasks phosphorylated residues to alkaline phosphatase, permitting dephosphorylation and increasing the bioavailability of iron.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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