|Related Categories||Bacteria, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,|
|composition||Protein, ~5% Lowry-TCA|
|solubility||H2O: soluble10 mg/mL|
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Package size based on protein content.
When reconstituted at 1 mg/mL in water, solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.
One unit increases adenylate cyclase activity 6-fold, measured as [3H]-cAMP present, using approx. 70,000 CHO cells after incubation for 90 min at 37 °C with [3H]-adenine followed by a 15 min incubation with 1 mM 3-isobutyl-1-methylxanthi
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA
Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
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Certificate of Analysis
Certificate of Origin
The Liposome PCR Assay Is More Sensitive Than The Vibrio Cholerae Enterotoxin And Escherichia Coli Heat-labile Enterotoxin Reversed Passive Latex Agglutination Test At Detecting Cholera Toxin In Feces And Water. Evers, D.L., et al. J. Clin. Microbiol. 48, 4620-2, (2010)
Cholera Toxin Regulates A Signaling Pathway Critical For The Expansion Of Neural Stem Cell Cultures From The Fetal And Adult Rodent Brains. Androutsellis-Theotokis, A., et al. PLoS ONE 5, e10841, (2010)
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Limbird, L.E., et al. Proc. Natl. Acad. Sci. U. S. A. 77, 775-779, (1980)
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