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  • C8102 - Anti-CIDE-B, C-Terminal antibody produced in rabbit

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C8102 Sigma

Anti-CIDE-B, C-Terminal antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Cell Death-Inducing DFF-like Effector B

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to DNA Fragmentation,
species reactivity   mouse
application(s)   western blot: 1 μg/mL using mouse heart tissue lysate
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 25 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Cideb(12684)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 204-219 of the C-terminal of mouse CIDE-B.

General description

CIDE-B is consists of a twisted five-stranded β-sheet and two α helices arranged in an α⁄β roll fold. It is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Application

Anti-CIDE-B, C-Terminal antibody is suitable for western blot at a dilution of 1 μg/mL by using mouse heart tissue lysate.

Biochem/physiol Actions

Apoptosis is related to many diseases and induced by a family of death receptors and their ligands. CIDE-B induces DNA fragmentation and activates apoptosis in mammalian cells. The apoptotic activity of CIDE-B is inhibited by DFF40/CAD (DNA Fragmentation Factor 40/caspase-activated DNase).

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