|Related Categories||Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, C-CH,|
|Gene Information||human ... DRD2(1813), HRH1(3269)|
Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.
5, 25, 100 g in glass bottle
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P260-P284-P301 + P310-P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||25-26|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 2811PIH 6.1 / PGI|
Importance of the interaction protein-protein of the CaM-PDE1A and CaM-MLCK complexes in the development of new anti-CaM drugs. González-Andrade M, Mata R, Madariaga-Mazón A, et al. J. Mol. Recognit. 26(4), 165-74, (2013)
Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. Suzuki H, Gen K, and Inoue Y J. Psychopharmacol. 27(4), 396-400, (2013)
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs. Basta-Kaim A, Szczęsny E, Leśkiewicz M, et al. Pharmacol. Rep. 64(6), 1400-10, (2012)
Exposure of chlorpromazine to 266 nm laser beam generates new species with antibacterial properties: contributions to development of a new process for drug discovery. Pascu ML, Danko B, Martins A, et al. PLoS ONE 8(2), e55767, (2013)
[Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence]. Li X, Yang Y, and Zhou K Se Pu 30(9), 938-42, (2012)
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice. Villarreal CF, Funez MI, Cunha Fde Q, et al. Pharmacol. Biochem. Behav. 103(3), 678-83, (2013)
Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis. Amaral L and Molnar J Expert Rev. Anti. Infect. Ther. 10(8), 869-73, (2012)
In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures. Broeders JJ, Blaauboer BJ, and Hermens JL Toxicol. In Vitro 27(3), 1057-64, (2013)
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Palacios, M., et al. Biochem. Biophys. Res. Commun. 196, 280, (1993)
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