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C8180 Sigma

Cholera Toxin A Subunit from Vibrio cholerae

lyophilized powder

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Properties

Related Categories Bacteria, Bacteria-derived adjuvants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH,
form   lyophilized powder
composition   Protein, ~5% Lowry
availability   not available in Japan
impurities   ≤0.5% Cholera toxin B subunit (SDS-PAGE)
storage temp.   2-8°C

Description

Analysis Note

ADP-ribosylation activity: Measured by ADP-ribosylation of poly-L-arginine following the incorporation of ADP-ribose from NAD-(adenine-UL-14C) to TCA-precipitable material. One μg of cholera toxin A subunit will cause the incorporation of at least 2 picomoles of ADP-ribose in 30 min at 30 °C.

Biochem/physiol Actions

Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase

Packaging

0.5 mg in glass bottle

Reconstitution

When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.

Physical form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
Protocols & Articles
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