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  • C8227 - Anti-CXCR4 (Fusin), N-Terminal antibody produced in rabbit

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C8227 Sigma

Anti-CXCR4 (Fusin), N-Terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Description

Immunogen

synthetic peptide corresponding to amino acids 1-14 of the N-terminal of human CXCR4.

General description

Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin), N-Terminal antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. It can also be used in immunoprecipitation. Rabbit anti- CXCR4 (Fusin), N-Terminal antibody reacts specifically with human CXCR4.

Physical form

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Application

Anti-CXCR4 (Fusin), N-Terminal antibody can be used in immunoblotting and immunocytochemistry.

Other Notes

The antigen (receptor) is also termed fusin, LESTER and HUMSTR.

Biochem/physiol Actions

CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.

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