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C8273 Sigma

Cytochalasin D

from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

Synonym: Zygosporin A

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Properties

Related Categories Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,
Quality Level   PREMIUM
biological source   from Zygosporium mansonii
InChI Key   SDZRWUKZFQQKKV-JHADDHBZSA-N
assay   ≥98% (TLC and HPLC)
form   powder
solubility   DMSO: soluble
  ethanol: soluble
Mode of action   DNA synthesis | interferes
storage temp.   −20°C

Description

Biochem/physiol Actions

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.

Packaging

1, 5, 10 mg in serum bottle

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGII
WGK Germany 
3
RTECS 
GZ4850000
Protocols & Articles

Articles

Fluorescent Live Cell Imaging of Cytoskeleton Structure Proteins using LentiBrite™ Lentiviral Biosensors

Cell analysis of the dynamics of subcellular structures has been revolutionized in the past 15 years by the development and refinement of genetically-encoded fusions between fluorescent proteins (GFP...
Keywords: Apoptosis, Cloning, Fluorescent microscopy, Gene expression, Immunocytochemistry, Immunofluorescence, Microscopy, Rearrangements, Tagged proteins, Transduction, Transfection

Peer-Reviewed Papers
15

References

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C2618 Cytochalasin D, Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO, 0.2 μm filtered

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